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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 47 - 59 (13page)
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초록· 키워드
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Background: The South Korean criteria for occupational diseases were amended in July 2013. These criteria included formaldehyde as a newly defined occupational carcinogen, based on cases of “leukemia or nasopharyngeal cancer caused by formaldehyde exposure”. This inclusion was based on the Internal Agency for Research on Cancer classification, which classified formaldehyde as definite human carcinogen for nasopharyngeal cancer in 2004 and leukemia in 2012.
Methods: We reviewed reports regarding the causal relationship between occupational exposure to formaldehyde in Korea and the development of these cancers, in order to determine whether these cases were work-related.
Results: Previous reports regarding excess mortality from nasopharyngeal cancer caused by formaldehyde exposure seemed to be influenced by excess mortality from a single plant. The recent meta-risk for nasopharyngeal cancer was significantly increased in case-control studies, but was null for cohort studies (excluding unexplained clusters of nasopharyngeal cancers). A recent analysis of the largest industrial cohort revealed elevated risks of both leukemia and Hodgkin lymphoma at the peak formaldehyde exposure, and both cancers exhibited significant dose-response relationships. A nested case-control study of embalmers revealed that mortality from myeloid leukemia increased significantly with increasing numbers of embalms and with increasing formaldehyde exposure. The recent metarisks for all leukemia and myeloid leukemia increased significantly. In South Korea, a few cases were considered occupational cancers as a result of mixed exposures to various chemicals (e.g., benzene), although no cases were compensated for formaldehyde exposure. The peak formaldehyde exposure levels in Korea were 2.70–14.8 ppm in a small number of specialized studies, which considered anatomy students, endoscopy employees who handled biopsy specimens, and manufacturing workers who were exposed to high temperatures.
Conclusion: Additional evidence is needed to confirm the relationship between formaldehyde exposure and nasopharyngeal cancer. All lymphohematopoietic malignancies, including leukemia, should be considered in cases with occupational formaldehyde exposure.
Methods: We reviewed reports regarding the causal relationship between occupational exposure to formaldehyde in Korea and the development of these cancers, in order to determine whether these cases were work-related.
Results: Previous reports regarding excess mortality from nasopharyngeal cancer caused by formaldehyde exposure seemed to be influenced by excess mortality from a single plant. The recent meta-risk for nasopharyngeal cancer was significantly increased in case-control studies, but was null for cohort studies (excluding unexplained clusters of nasopharyngeal cancers). A recent analysis of the largest industrial cohort revealed elevated risks of both leukemia and Hodgkin lymphoma at the peak formaldehyde exposure, and both cancers exhibited significant dose-response relationships. A nested case-control study of embalmers revealed that mortality from myeloid leukemia increased significantly with increasing numbers of embalms and with increasing formaldehyde exposure. The recent metarisks for all leukemia and myeloid leukemia increased significantly. In South Korea, a few cases were considered occupational cancers as a result of mixed exposures to various chemicals (e.g., benzene), although no cases were compensated for formaldehyde exposure. The peak formaldehyde exposure levels in Korea were 2.70–14.8 ppm in a small number of specialized studies, which considered anatomy students, endoscopy employees who handled biopsy specimens, and manufacturing workers who were exposed to high temperatures.
Conclusion: Additional evidence is needed to confirm the relationship between formaldehyde exposure and nasopharyngeal cancer. All lymphohematopoietic malignancies, including leukemia, should be considered in cases with occupational formaldehyde exposure.
목차
Abstract
Background
Methods
Results
Discussion
Conclusion
References
참고문헌 (70)
참고문헌 신청
Song J / 2014 / The scope and specific criteria of compensation for occupational diseases in Korea / J Korean Med Sci 29(Suppl):S32~S39
Kim I / 2014 / Compensation for occupational cancer / J Korean Med Sci 29(Suppl):S40~S46
IARC / 2006 / Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol / Monogr Eval Carcinog Risks Hum 88:39~325
IARC / 2012 / A review of human carcinogens: chemical agents and related occupations: formadehyde / Monogr Eval Carcinog Risks Hum 100F:401~435
EPA / 2010 / IRIS toxicological review of formaldehyde-inhalation assessment (external review of draft) / U.S. Environmental Protection Agency
Kim I / 2014 / Compensation for occupational cancer / J Korean Med Sci 29(Suppl):S40~S46
IARC / 2006 / Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol / Monogr Eval Carcinog Risks Hum 88:39~325
IARC / 2012 / A review of human carcinogens: chemical agents and related occupations: formadehyde / Monogr Eval Carcinog Risks Hum 100F:401~435
EPA / 2010 / IRIS toxicological review of formaldehyde-inhalation assessment (external review of draft) / U.S. Environmental Protection Agency
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UCI(KEPA) : I410-ECN-0101-2018-517-001767843