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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 16 - 23 (8page)
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Purpose: To investigate the effects of anthocyanins extracted from black soybean,which have antioxidant activity, on apoptosis in vitro (in hormone refractoryprostate cancer cells) and on tumor growth in vivo (in athymic nude mouse xenograftmodel). Materials and Methods: The growth and viability of DU-145 cells treated with anthocyanins were assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and apoptosis was assessed by DNA laddering. Immunoblotting was conducted to evaluate differences in the expressions of p53, Bax, Bcl, androgen receptor (AR), and prostate specific antigen(PSA). To study the inhibitory effects of anthocyanins on tumor growth in vivo, DU-145 tumor xenografts were established in athymic nude mice. The anthocyaningroup was treated with daily oral anthocyanin (8 mg/kg) for 14 weeks. After 2 weeks of treatment, DU-145 cells (2×106) were inoculated subcutaneouslyinto the right flank to establish tumor xenografts. Tumor dimensions were measuredtwice a week using calipers and volumes were calculated. Results: Anthocyanintreatment of DU-145 cells resulted in 1) significant increase in apoptosis in a dose-dependent manner, 2) significant decrease in p53 and Bcl-2 expressions (with increased Bax expression), and 3) significant decrease in PSA and AR expressions.
In the xenograft model, anthocyanin treatment significantly inhibit tumorgrowth. Conclusion: This study suggests that anthocyanins from black soybeaninhibit the progression of prostate cancer in vitro and in a xenograft model.
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참고문헌 (25)
참고문헌 신청
Akao Y / 1994 / Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes / Cancer Res 54
Alessandri G / 1987 / Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells / Cancer Res 47 : 4243 ~ 4247
Bostwick DG / 2000 / Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer / Cancer 89 : 123 ~ 134
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 (Pt 1) : 1 ~ 16
Danial NN / 2007 / BCL-2 family proteins: critical checkpoints of apoptotic cell death / Clin Cancer Res 13 : 7254 ~ 7263
Alessandri G / 1987 / Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells / Cancer Res 47 : 4243 ~ 4247
Bostwick DG / 2000 / Antioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer / Cancer 89 : 123 ~ 134
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 (Pt 1) : 1 ~ 16
Danial NN / 2007 / BCL-2 family proteins: critical checkpoints of apoptotic cell death / Clin Cancer Res 13 : 7254 ~ 7263
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