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논문 기본 정보
- 자료유형
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- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제3호
- 발행연도
- 2019.1
- 수록면
- 161 - 169 (9page)
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Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether FC has anti-adipogenic effects in 3T3-L1 adipocytes and whether it ameliorates lipid accumulation in highfat diet (HFD)-induced obese mice. FC notably increased the levels of glycerol in the culture supernatants and markedly reduced lipid accumulation in 3T3-L1 adipocytes. FC differentially inhibited the expressions of adipogenesis-related genes, including the peroxisome proliferator-activated receptor proteins, CCAAT/enhancer-binding proteins, and sterol regulatory element-binding proteins. FC markedly reduced the expressions of lipid synthesis-related genes, such as the fatty acid binding protein, lipoprotein lipase, and fatty acid synthase. Furthermore, FC significantly increased the expressions of lipolysis-related genes, such as the hormone-sensitive lipase, Aquaporin- 7, and adipose triglyceride lipase. In HFD-induced obese mice, intraperitoneal injections of FC decreased both the body weight and visceral adipose tissue weight. FC administration significantly reduced lipid accumulation. Moreover, FC could dosedependently and differentially regulate the expressions of lipid metabolism-related transcription factors. All these data indicated that FC exhibited anti-obesity effects through modulating adipogenesis and lipolysis.
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참고문헌 (35)
참고문헌 신청
Gangadaran S / 2017 / A high fat diet enriched with sea cucumber gut powder provides cardio-protective and anti-obesity effects in C57BL/6 mice / Food Res Int 99:799~806
Imai N / 2017 / Hepatocytespecific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model / Histochem Cell Biol 148:219~227
Wan-Guo Yu / 2015 / Dimethyl Cardamonin Exhibits Anti-inflammatory Effects via Interfering with the PI3K-PDK1-PKCα Signaling Pathway / Biomolecules & Therapeutics 23(6):549~556
Chandrashekaran V / 2017 / HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease / Redox Biol 13:8~19
Tian F / 2017 / Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function / Biochem Biophys Res Commun 491:8~14
Imai N / 2017 / Hepatocytespecific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model / Histochem Cell Biol 148:219~227
Wan-Guo Yu / 2015 / Dimethyl Cardamonin Exhibits Anti-inflammatory Effects via Interfering with the PI3K-PDK1-PKCα Signaling Pathway / Biomolecules & Therapeutics 23(6):549~556
Chandrashekaran V / 2017 / HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease / Redox Biol 13:8~19
Tian F / 2017 / Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function / Biochem Biophys Res Commun 491:8~14
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