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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 81 - 89 (9page)
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Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events.
Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry.We also evaluated the effects of BIOGF1K on the activator protein-1 signaling pathway, which plays an important role in photoaging, by immunoblot analysis and luciferase reporter gene assays.
Results: Treatment of UVB-irradiated NIH3T3 fibroblasts with BIOGF1K prevented UVB-induced cell death, inhibited apoptosis, suppressed morphological changes, reduced melanin secretion, restored the levels of type I procollagen and sirtuin 1, and prevented mRNA upregulation of MMP-1, MMP-2, and cyclo-oxygenase-2; these effects all occurred in a dose-dependent manner. In addition, BIOGF1K markedly reduced activator-protein-1-mediated luciferase activity and decreased the activity of mitogen-activated protein kinases (extracellular response kinase, p38, and C-Jun N-terminal kinase).
Conclusion: Our results strongly suggest that BIOGF1K has anti-photoaging activity and that BIOGF1K could be used in anti-aging cosmeceutical preparations.
Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry.We also evaluated the effects of BIOGF1K on the activator protein-1 signaling pathway, which plays an important role in photoaging, by immunoblot analysis and luciferase reporter gene assays.
Results: Treatment of UVB-irradiated NIH3T3 fibroblasts with BIOGF1K prevented UVB-induced cell death, inhibited apoptosis, suppressed morphological changes, reduced melanin secretion, restored the levels of type I procollagen and sirtuin 1, and prevented mRNA upregulation of MMP-1, MMP-2, and cyclo-oxygenase-2; these effects all occurred in a dose-dependent manner. In addition, BIOGF1K markedly reduced activator-protein-1-mediated luciferase activity and decreased the activity of mitogen-activated protein kinases (extracellular response kinase, p38, and C-Jun N-terminal kinase).
Conclusion: Our results strongly suggest that BIOGF1K has anti-photoaging activity and that BIOGF1K could be used in anti-aging cosmeceutical preparations.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (57)
참고문헌 신청
[학술지(정기간행물)] - Asadamongkol B / 2014 / The development of hyperbaric oxygen therapy for skin rejuvenation and treatment of photoaging / Med Gas Res 4 : 1 ~
[학술지(정기간행물)] - Bosch R / 2015 / Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals / Antioxidants 4 : 248 ~ 268
[학술지(정기간행물)] - Chung KW / 2014 / Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation / J Gerontol A Biol Sci Med Sci 70 : 959 ~ 968
[학술지(정기간행물)] - Yan Y / 2013 / Receptor interacting protein 1 involved in ultraviolet B induced NIH3T3 cell apoptosis through expression of matrix metalloproteinases and reactive oxygen species production / Chin Med J 126 : 4327 ~ 4333
[학술지(정기간행물)] - Brenneisen P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases / Ann N Y Acad Sci 973 : 31 ~ 43
[학술지(정기간행물)] - Bosch R / 2015 / Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals / Antioxidants 4 : 248 ~ 268
[학술지(정기간행물)] - Chung KW / 2014 / Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation / J Gerontol A Biol Sci Med Sci 70 : 959 ~ 968
[학술지(정기간행물)] - Yan Y / 2013 / Receptor interacting protein 1 involved in ultraviolet B induced NIH3T3 cell apoptosis through expression of matrix metalloproteinases and reactive oxygen species production / Chin Med J 126 : 4327 ~ 4333
[학술지(정기간행물)] - Brenneisen P / 2002 / Ultraviolet-B irradiation and matrix metalloproteinases / Ann N Y Acad Sci 973 : 31 ~ 43
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UCI(KEPA) : I410-ECN-0101-2018-524-001744587