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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 146 - 146 (1page)
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Natural products with antioxidant activity have received a great attention for photoaging therapy because this disease is well known as premature skin changes after continuous and long-term repeated exposure to chronic ultraviolet (UV)A and UVB. To investigate therapeutic effects of methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) against UV-induced photoaging, alterations on antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances and anti-inflammatory response were assessed in normal human dermal fibroblasts (NHDFs) cells and nude mice treated with MED. MED showed the high level of tannin content (879.27 mg/g) and high free radical scavenging activity to DPPH (IC50 = 7.06 μg/ml). UV-induced alterations on NO concentration, SOD activity and expression, and Nrf2 phosphorylation were remarkably recovered by MED treated NHDF cells. The number of apoptotic cells, Bax/Bcl-2 ratio and cleaved Cas-3/Cas-3 r ... 전체 초록 보기
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