지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 566 - 571 (6page)
이용수
초록· 키워드
오류제보하기
Background: A number of reports have described the protective effects of ginsenoside Rg1 (Rg1) in Alzheimer’s disease (AD). However, the protective mechanisms of Rg1 in AD remain elusive.
Methods: To investigate the potential mechanisms of Rg1 in b-amyloid peptide-treated SH-SY5Y cells, a comparative proteomic analysis was performed using stable isotope labeling with amino acids in cell culture combined with nano-LC-MS/MS.
Results: We identified a total of 1,149 proteins in three independent experiments. Forty-nine proteins were significantly altered by Rg1 after exposure of the cells to b-amyloid peptides. The protein interaction network analysis showed that these altered proteins were clustered in ribosomal proteins, mitochondria, the actin cytoskeleton, and splicing proteins. Among these proteins, mitochondrial proteins containing HSD17B10, AARS2, TOMM40, VDAC1, COX5A, and NDUFA4 were associated with mitochondrial dysfunction in the pathogenesis of AD.
Conclusion: Our results suggest that mitochondrial proteins may be related to the protective mechanisms of Rg1 in AD.
Methods: To investigate the potential mechanisms of Rg1 in b-amyloid peptide-treated SH-SY5Y cells, a comparative proteomic analysis was performed using stable isotope labeling with amino acids in cell culture combined with nano-LC-MS/MS.
Results: We identified a total of 1,149 proteins in three independent experiments. Forty-nine proteins were significantly altered by Rg1 after exposure of the cells to b-amyloid peptides. The protein interaction network analysis showed that these altered proteins were clustered in ribosomal proteins, mitochondria, the actin cytoskeleton, and splicing proteins. Among these proteins, mitochondrial proteins containing HSD17B10, AARS2, TOMM40, VDAC1, COX5A, and NDUFA4 were associated with mitochondrial dysfunction in the pathogenesis of AD.
Conclusion: Our results suggest that mitochondrial proteins may be related to the protective mechanisms of Rg1 in AD.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - Correa MS / 2015 / Psychophysiological correlates of cognitive deficits in family caregivers of patients with Alzheimer disease / Neuroscience 286 : 371 ~ 382
[학술지(정기간행물)] - Mucke L / 2009 / Neuroscience : Alzheimer’s disease / Nature 461 : 895 ~ 897
[학술지(정기간행물)] - Piaceri I / 2012 / Mitochondria and Alzheimer’s disease / J Neurol Sci 322 : 31 ~ 34
[학술지(정기간행물)] - Selkoe DJ / 2003 / Alzheimer’s disease : molecular understanding predicts amyloid-based therapeutics / Annu Rev Pharmacol Toxicol 43 : 545 ~ 584
[학술지(정기간행물)] - Masters CL / 1985 / Amyloid plaque core protein in Alzheimer disease and Down syndrome / Proc Natl Acad Sci U S A 82 : 4245 ~ 4249
[학술지(정기간행물)] - Mucke L / 2009 / Neuroscience : Alzheimer’s disease / Nature 461 : 895 ~ 897
[학술지(정기간행물)] - Piaceri I / 2012 / Mitochondria and Alzheimer’s disease / J Neurol Sci 322 : 31 ~ 34
[학술지(정기간행물)] - Selkoe DJ / 2003 / Alzheimer’s disease : molecular understanding predicts amyloid-based therapeutics / Annu Rev Pharmacol Toxicol 43 : 545 ~ 584
[학술지(정기간행물)] - Masters CL / 1985 / Amyloid plaque core protein in Alzheimer disease and Down syndrome / Proc Natl Acad Sci U S A 82 : 4245 ~ 4249
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease
Journal of Ginseng Research
2016 .01
-
Integration of virtual screening and proteomics reveals potential targets and pathways for ginsenoside Rg₁ against myocardial ischemia
Journal of Ginseng Research
2024 .07
-
A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts
Journal of Ginseng Research
2019 .06
-
Ginsenoside Rg1 suppresses early stage of adipocyte development via activation of C/EBP homologous protein-10 in 3T3-L1 and attenuates fat accumulation in high fat diet-induced obese zebrafish
Journal of Ginseng Research
2017 .01
-
Ginsenoside Rg3 suppresses mast cellemediated allergic inflammation via mitogen-activated protein kinase signaling pathway
Journal of Ginseng Research
2019 .04
-
Ginsenoside Rg1 enhances the healing of injured tendon in achilles tendinitis through the activation of IGF1R signaling mediated by oestrogen receptor
Journal of Ginseng Research
2022 .07
-
Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes
Journal of Ginseng Research
2019 .10
-
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway
Journal of Ginseng Research
2022 .03
-
Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes
Diabetes and Metabolism Journal
2016 .01
-
Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1
Journal of Ginseng Research
2023 .03
-
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production
Journal of Ginseng Research
2022 .01
-
Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice
Journal of Ginseng Research
2019 .06
-
Ginsenoside Rg1 alleviates Ab deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice
Journal of Ginseng Research
2021 .11
-
Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
Journal of Ginseng Research
2015 .10
-
Enhanced Rg3 negatively regulates Th1 cell responses
Journal of Ginseng Research
2019 .01
-
Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway
Journal of Ginseng Research
2019 .10
-
Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions
Journal of Ginseng Research
2018 .04
-
Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells
Journal of Ginseng Research
2016 .07
-
Proteomic analyses reveal that ginsenoside Rg3(S) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin
Journal of Ginseng Research
2020 .01
-
Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152
Journal of Ginseng Research
2023 .07
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Aβ42로 유도된 알츠하이머 마우스 모델에서 이중 가공 인삼열매 추출물의 학습 및 기억 손실 개선 효과
장수길
,
안정원
,
조보람
외 7명
한국식품과학회지
2019
.04
A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages
Ji-Hyun Min
,
Hui-Jin Cho
,
Young-Su Yi
Journal of Ginseng Research
2022
.09
각질 형성 세포에서 TNF-ɑ로 유도된 염증 반응에 대한 흑삼 추출물의 항염증 효과
최원영
,
이계원
,
권득상
외 2명
한국식품영양과학회지
2021
.10
Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide
Kenneth Kin Leung Kwan
,
Huang Yun
,
Tina Ting Xia Dong
외 2명
Journal of Ginseng Research
2021
.07
Korean Red Ginseng and Portulaca oleracea Extracts Attenuate Lipopolysaccharide-induced Inflammation via Downregulation of Nuclear Factor Kappa-B and the Mitogen-activated Protein Kinase Signaling Pathway in Macrophage Cell Line RAW 264.7
H M A
,
if Ullah
,
Tae-Hwan Kim
외 3명
대한의생명과학회지
2021
.06
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-524-001599342