지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 665 - 675 (11page)
이용수
초록· 키워드
오류제보하기
Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for the treatment of Alzheimer’s disease (AD). However, the protective effect of Rg1 on neurodegeneration in AD and its mechanism of action are still incompletely understood.
Methods: Wild type (WT) and APP/PS1 AD mice, from 6 to 9 months old, were used in the experiment. The open field test (OFT) and Morris water maze (MWM) were used to detect behavioral changes. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Immunofluorescence, western blotting, and quantitative real-time polymerase chain reaction (q-PCR) were used to examine postsynaptic density 95 (PSD95) expression, amyloid beta (Aβ) deposition, Tau and phosphorylated Tau (p-Tau) expression, reactive oxygen species (ROS) production, and NAPDH oxidase 2 (NOX2) expression.
Results: Rg1 treatment for 12 weeks significantly ameliorated cognitive impairments and neuronal damage and decreased the p-Tau level, amyloid precursor protein (APP) expression, and Aβ generation in APP/PS1 mice. Meanwhile, Rg1 treatment significantly decreased the ROS level and NOX2 expression in the hippocampus and cortex of APP/PS1 mice.
Conclusions: Rg1 alleviates cognitive impairments, neuronal damage, and reduce Aβ deposition by inhibiting NOX2 activation in APP/PS1 mice.
Methods: Wild type (WT) and APP/PS1 AD mice, from 6 to 9 months old, were used in the experiment. The open field test (OFT) and Morris water maze (MWM) were used to detect behavioral changes. Neuronal damage was assessed by hematoxylin and eosin (H&E) and Nissl staining. Immunofluorescence, western blotting, and quantitative real-time polymerase chain reaction (q-PCR) were used to examine postsynaptic density 95 (PSD95) expression, amyloid beta (Aβ) deposition, Tau and phosphorylated Tau (p-Tau) expression, reactive oxygen species (ROS) production, and NAPDH oxidase 2 (NOX2) expression.
Results: Rg1 treatment for 12 weeks significantly ameliorated cognitive impairments and neuronal damage and decreased the p-Tau level, amyloid precursor protein (APP) expression, and Aβ generation in APP/PS1 mice. Meanwhile, Rg1 treatment significantly decreased the ROS level and NOX2 expression in the hippocampus and cortex of APP/PS1 mice.
Conclusions: Rg1 alleviates cognitive impairments, neuronal damage, and reduce Aβ deposition by inhibiting NOX2 activation in APP/PS1 mice.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease
Journal of Ginseng Research
2016 .01
-
Global analysis of ginsenoside Rg1 protective effects in b-amyloid-treated neuronal cells
Journal of Ginseng Research
2017 .10
-
Ginsenoside Rg1 suppresses early stage of adipocyte development via activation of C/EBP homologous protein-10 in 3T3-L1 and attenuates fat accumulation in high fat diet-induced obese zebrafish
Journal of Ginseng Research
2017 .01
-
Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice
Journal of Ginseng Research
2019 .06
-
Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLCeCNeNFAT1 signaling in T2DM mice
Journal of Ginseng Research
2023 .05
-
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice
Journal of Ginseng Research
2022 .07
-
Ginsenoside Rg1 enhances the healing of injured tendon in achilles tendinitis through the activation of IGF1R signaling mediated by oestrogen receptor
Journal of Ginseng Research
2022 .07
-
Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice
Journal of Ginseng Research
2021 .11
-
Ginsenoside Rg1 ameliorates Alzheimer’s disease pathology via restoring mitophagy
Journal of Ginseng Research
2023 .05
-
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway
Journal of Ginseng Research
2022 .03
-
Longevity, tumor, and physical vitality in rats consuming ginsenoside Rg1
Journal of Ginseng Research
2023 .03
-
Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
Journal of Ginseng Research
2015 .10
-
Ginsenoside Rg3 suppresses mast cellemediated allergic inflammation via mitogen-activated protein kinase signaling pathway
Journal of Ginseng Research
2019 .04
-
Ginsenoside Rg3 attenuates skin disorders via down-regulation of MDM2/HIF1a signaling pathway
Journal of Ginseng Research
2021 .09
-
Ginsenoside Rg1 Epigenetically Modulates Smad7 Expression in Liver Fibrosis via MicroRNA-152
Journal of Ginseng Research
2023 .07
-
β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/ presenilin 1 mice
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes
Journal of Ginseng Research
2019 .10
-
Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production
Journal of Ginseng Research
2022 .01
-
Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
Journal of Ginseng Research
2018 .01
-
Integration of virtual screening and proteomics reveals potential targets and pathways for ginsenoside Rg₁ against myocardial ischemia
Journal of Ginseng Research
2024 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2022-524-001132986