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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 496 - 502 (7page)
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초록· 키워드
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Background: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and immunomodulatory properties. In this study, we investigated the antiviral effects of 15 ginsenosides and compound K on gammaherpesvirus.
Methods: The antiviral activity of ginsenosides was examined using the plaque-forming assay and by analyzing the expression of the lytic gene.
Results: 20(R)-Ginsenoside Rh2 inhibited the replication and proliferation of murine gammaherpesvirus 68 (MHV-68), and its half-maximal inhibitory concentration (IC<SUB>50</SUB>) against MHV-68 was estimated to be 2.77 mM. In addition, 20(R)-ginsenoside Rh2 inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpesvirus in the Kaposi’s sarcoma-associated herpesvirus(KSHV)-positive cell line BC3.
Conclusion: Our results indicate that 20(R)-ginsenoside Rh2 can inhibit the replication of mouse and human gammaherpesviruses, and thus, has the potential to treat gammaherpesvirus infection.
Methods: The antiviral activity of ginsenosides was examined using the plaque-forming assay and by analyzing the expression of the lytic gene.
Results: 20(R)-Ginsenoside Rh2 inhibited the replication and proliferation of murine gammaherpesvirus 68 (MHV-68), and its half-maximal inhibitory concentration (IC<SUB>50</SUB>) against MHV-68 was estimated to be 2.77 mM. In addition, 20(R)-ginsenoside Rh2 inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpesvirus in the Kaposi’s sarcoma-associated herpesvirus(KSHV)-positive cell line BC3.
Conclusion: Our results indicate that 20(R)-ginsenoside Rh2 can inhibit the replication of mouse and human gammaherpesviruses, and thus, has the potential to treat gammaherpesvirus infection.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (41)
참고문헌 신청
[학술지(정기간행물)] - 이민화 / 2011 / Antiviral Effect of Korean Red Ginseng Extract and Ginsenosides on Murine Norovirus and Feline Calicivirus as Surrogates for Human Norovirus / Journal of Ginseng Research 35 (4) : 429 ~ 435
[학술지(정기간행물)] - Jin SH / 1999 / Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice / J Ethnopharmacol 66 : 123 ~ 129
[학술지(정기간행물)] - Surh YJ / 2003 / Dietary and medicinal antimutagens and anticarcinogens:molecular mechanisms and chemopreventive potentialehighlights of a symposium / Mutat Res 523-524 : 1 ~ 8
[학술지(정기간행물)] - Chanoh Jeon / 2011 / T Cell Stimulatory Effects of Korean Red Ginseng through Modulation of Myeloid-Derived Suppressor Cells / Journal of Ginseng Research 35 (4) : 462 ~ 470
[학술지(정기간행물)] - Helms S / 2004 / Cancer prevention and therapeutics : Panax ginseng / Altern Med Rev 9 : 259 ~ 274
[학술지(정기간행물)] - Jin SH / 1999 / Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice / J Ethnopharmacol 66 : 123 ~ 129
[학술지(정기간행물)] - Surh YJ / 2003 / Dietary and medicinal antimutagens and anticarcinogens:molecular mechanisms and chemopreventive potentialehighlights of a symposium / Mutat Res 523-524 : 1 ~ 8
[학술지(정기간행물)] - Chanoh Jeon / 2011 / T Cell Stimulatory Effects of Korean Red Ginseng through Modulation of Myeloid-Derived Suppressor Cells / Journal of Ginseng Research 35 (4) : 462 ~ 470
[학술지(정기간행물)] - Helms S / 2004 / Cancer prevention and therapeutics : Panax ginseng / Altern Med Rev 9 : 259 ~ 274
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UCI(KEPA) : I410-ECN-0101-2018-524-001599251