지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 462 - 470 (9page)
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초록· 키워드
오류제보하기
Myeloid-derived suppressor cells (MDSCs) actively suppress immune cells and have been considered as an impediment to successful cancer immunotherapy. Many approaches have been made to overcome such immunosuppressive factors and to exert effective anti-tumor effects, but the possibility of using medicinal plants for this purpose has been overlooked. Korean red ginseng (KRG) is widely known to possess a variety of pharmacological properties, including immunoboosting and anti-tumor activities. However, Little has been done to assess the anti-tumor activity of KRG on MDSCs. Therefore, we examined the effects of KRG on MDSCs in tumor-bearing mice and evaluated immunostimulatory and anti-tumor activities of KRG through MDSC modulation. The data show that intraperitoneal administration of KRG compromises MDSC function and induces T cell proliferation and the secretion ofIL-2 and IFN-y, while it does not exhibit direct cytotoxicity on tumor cells and reduced MDSC accumulation. MDSCs isolated from KRG-treated mice also express significantly lower levels of inducible nitric oxide synthase and IL-I 0 accompanied by a decrease in nitric oxide production compared with control. Taken together, the present study demonstrates that KRG enhances T cell function by inhibiting the immunosuppressive activity of MDSCs and suggests that although KRG alone does not exhibit direct anti-tumor effects, the use of KRG together with conventional chemo- or immunotherapy may provide better outcomes to cancer patients through MDSC modulation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (42)
참고문헌 신청
1. [학술지(정기간행물)] - Gabrilovich DI / 2009 / Myeloid-derived suppressor cells as regulators of the immune system / Nat Rev Immunol 9 : 162 ~ 174
2. [학술지(정기간행물)] - Marigo I / 2008 / Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells / Immunol Rev 222 : 162 ~ 179
3. [학술지(정기간행물)] - Haile LA / 2008 / Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway / Gastroenterology 135 : 871 ~ 881
4. [학술지(정기간행물)] - Angulo I / 2000 / Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+ cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice / Blood 95 : 212 ~ 220
5. [학술지(정기간행물)] - Zhu B / 2007 / CD11b+Ly-6Chi suppressive monocytes in experimental autoimmune encephalomyelitis / J Immunol 179 : 5228 ~ 5237
2. [학술지(정기간행물)] - Marigo I / 2008 / Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells / Immunol Rev 222 : 162 ~ 179
3. [학술지(정기간행물)] - Haile LA / 2008 / Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway / Gastroenterology 135 : 871 ~ 881
4. [학술지(정기간행물)] - Angulo I / 2000 / Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+ cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice / Blood 95 : 212 ~ 220
5. [학술지(정기간행물)] - Zhu B / 2007 / CD11b+Ly-6Chi suppressive monocytes in experimental autoimmune encephalomyelitis / J Immunol 179 : 5228 ~ 5237
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UCI(KEPA) : I410-ECN-0101-2013-524-001212640