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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 159 - 166 (8page)
- DOI
- 10.15188/kjopp.2017.06.31.3.159
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초록· 키워드
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Through this study, the authors investigated the anti-steatosis effects of the Amomum cardamomum ethyl acetate fraction in free fatty acids (FFAs)-induced human hepatocellular carcinoma HepG2 cells. The ethyl acetate fraction of Amomum cardamomum (ACEA) was extracted with 70% ethanol and then the extract was evaporated using a rotary evaporator prior to sequential fractionation. Human hepatocellular carcinoma were treated with different concentrations of ACEA in the presence and absence of FFAs. To demonstrate the reactive oxygen species (ROS) scavenging activity, DCFDA level was analyzed by using in vitro assay system. Cell viability, lipid accumulation, intracellular triglycerides, malondialdehyde (MDA), liver steatosis related signaling molecules and inflammatory cytokines such as interleukin (IL)-6, 8, tumor necrosis factor-alpha (TNF-α) were also investigated. As results, ACEA inhibited the FFAs-induced ROS, lipid accumulation, intracellular triglycerides, and MDA in a dose dependent manner. Treatment of human hepatocellular cells with ACEA induced the phosphorylation of 5" adenosine monophosphate-activated protein kinase (AMPK) and carnitine palmitoyltransferase I (CPT1) expression using western blot analysis. ACEA also potently suppressed the FFAs-induced inflammatory cytokines including IL-6, IL-8 and TNF-α. These results suggest that the ethyl acetate fraction of Amomum cardamoum extract own inhibitory effects of liver steatosis by inhibiting ROS, lipid accumulation, intracellular triglycerides, MDA through AMPK signaling and anti-inflammatory actions.
목차
서론
재료 및 방법
결과
고찰
결론
감사의 글
References
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Kumar A / 2012 / Patients with nonalcoholic fatty liver disease(NAFDL)have higher oxidative stress in comparison to chronic viral hepatitis / J Clin Exp Hepatol 3 : 12 ~ 18
[학술지(정기간행물)] - Li S / 2015 / The role of oxidative stress and antioxidants in liver diseases / Int J Mol Sci 16 : 26087 ~ 26124
[학술지(정기간행물)] - Griffith CM / 2006 / The role of nutritional therapy in alcoholic liver disease / Alcohol Res Health 29 : 296 ~ 306
[학술지(정기간행물)] - Matteoni CA / 1999 / Nonalcoholic fatty liver disease : a spectrum of clinical and pathological severity / Gastroenterology 116 : 1413 ~ 1419
[학술지(정기간행물)] - Marchesini G / 1999 / Association of nonalcoholic fatty liver diseases with insulin resistance / Am J Med 107 : 450 ~ 455
[학술지(정기간행물)] - Li S / 2015 / The role of oxidative stress and antioxidants in liver diseases / Int J Mol Sci 16 : 26087 ~ 26124
[학술지(정기간행물)] - Griffith CM / 2006 / The role of nutritional therapy in alcoholic liver disease / Alcohol Res Health 29 : 296 ~ 306
[학술지(정기간행물)] - Matteoni CA / 1999 / Nonalcoholic fatty liver disease : a spectrum of clinical and pathological severity / Gastroenterology 116 : 1413 ~ 1419
[학술지(정기간행물)] - Marchesini G / 1999 / Association of nonalcoholic fatty liver diseases with insulin resistance / Am J Med 107 : 450 ~ 455
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