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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.5
- 발행연도
- 2017.5
- 수록면
- 348 - 354 (7page)
이용수
이 논문의 연구 히스토리 (3)
2013
Streamline flow of portal vein affects the lobar distribution of colorectal liver metastases and has a clinical impact on survival
Jinsoo Rhu
,
Choon Hyuck David Kwon
,
Jae-Won Joh
외 7명
대한외과학회 학술대회 초록집
2013.05
학술대회자료
Streamline flow of portal vein affects the lobar distribution of colorectal liver metastases and hasa clinical impact on survival
Jinsoo Rhu
한국간담췌외과학회 학술대회지
2013.04
학술대회자료
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Purpose: It is believed that blood from the superior mesenteric vein and splenic vein mixes incompletely in the portal vein and maintains a streamline flow influencing its anatomic distribution. Although several experimental studies have demonstrated the existence of streamlining, clinical studies have shown conflicting results. We investigated whether streamlining of portal vein affects the lobar distribution of colorectal liver metastases and estimated its impact on survival.
Methods: Data of patients who underwent hepatectomy for colorectal liver metastases were retrospectively collected. The chi-square test was used for analyzing the distribution of metastasis. Cox analysis was used to identify risk factors of survival. Fisher exact test was used for subgroup analysis comparing hepatic recurrence.
Results: A total of 410 patients were included. The right-to-left ratio of liver metastases were 2.20:1 in right-sided colon cancer
and 1.39:1 in left-sided cancer (P = 0.017). Cox analyses showed that margin < 5 mm (P < 0.001; 95% confidence interval [CI], 1.648–4.884; hazard ratio [HR], 2.837), age ≥ 60 years (P = 0.004; 95% CI, 1.269–3.641; HR, 2.149), N2 status (P < 0.001, 95% CI, 1.598–4.215; HR, 2.595), tumor size ≥ 45 mm (P = 0.014; 95% CI, 1.159–3.758; HR, 2.087) and other metastasis (P = 0.012; 95% CI, 1.250–5.927; HR, 2.722) were risk factors of survival. However, in 70 patients who underwent right hemihepatectomy for solitary metastasis, left-sided colorectal cancer was a risk factor (P = 0.019; 95% CI, 1.293–17.956; HR, 4.818), and was associated with higher recurrence than right-sided cancer (43.1% and 15.8%, respectively, P = 0.049).
Conclusion: This study showed significant difference in lobar distribution of liver metastases between right colon cancer and left colorecral cancer. Furthermore, survival of left-sided colorectal cancer was poorer than that of right-sided cancer in patients who underwent right hemihepatectomy for solitary metastasis. These findings can be helpful for clinicians planning treatment strategy.
Methods: Data of patients who underwent hepatectomy for colorectal liver metastases were retrospectively collected. The chi-square test was used for analyzing the distribution of metastasis. Cox analysis was used to identify risk factors of survival. Fisher exact test was used for subgroup analysis comparing hepatic recurrence.
Results: A total of 410 patients were included. The right-to-left ratio of liver metastases were 2.20:1 in right-sided colon cancer
and 1.39:1 in left-sided cancer (P = 0.017). Cox analyses showed that margin < 5 mm (P < 0.001; 95% confidence interval [CI], 1.648–4.884; hazard ratio [HR], 2.837), age ≥ 60 years (P = 0.004; 95% CI, 1.269–3.641; HR, 2.149), N2 status (P < 0.001, 95% CI, 1.598–4.215; HR, 2.595), tumor size ≥ 45 mm (P = 0.014; 95% CI, 1.159–3.758; HR, 2.087) and other metastasis (P = 0.012; 95% CI, 1.250–5.927; HR, 2.722) were risk factors of survival. However, in 70 patients who underwent right hemihepatectomy for solitary metastasis, left-sided colorectal cancer was a risk factor (P = 0.019; 95% CI, 1.293–17.956; HR, 4.818), and was associated with higher recurrence than right-sided cancer (43.1% and 15.8%, respectively, P = 0.049).
Conclusion: This study showed significant difference in lobar distribution of liver metastases between right colon cancer and left colorecral cancer. Furthermore, survival of left-sided colorectal cancer was poorer than that of right-sided cancer in patients who underwent right hemihepatectomy for solitary metastasis. These findings can be helpful for clinicians planning treatment strategy.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61 : 69 ~ 90
[학술지(정기간행물)] - Tocchi A / 2004 / Hepatic resection in stage IV colorectal cancer : prognostic predictors of outcome / Int J Colorectal Dis 19 : 580 ~ 585
[학술지(정기간행물)] - Morise Z / 2006 / Does repeated surgery improve the prognosis of colorectal liver metastases? / J Gastrointest Surg 10 : 6 ~ 11
[학술지(정기간행물)] - Lee H / 2015 / Hepatectomy vs radiofrequency ablation for colorectal liver metastasis : a propensity score analysis / World J Gastroenterol 21 : 3300 ~ 3307
[학술지(정기간행물)] - Copher GH / 1928 / "Streamline"phenomena in the portal vein and selective distribution of portal blood in the liver / Arch Surg 17 : 408 ~ 419
[학술지(정기간행물)] - Tocchi A / 2004 / Hepatic resection in stage IV colorectal cancer : prognostic predictors of outcome / Int J Colorectal Dis 19 : 580 ~ 585
[학술지(정기간행물)] - Morise Z / 2006 / Does repeated surgery improve the prognosis of colorectal liver metastases? / J Gastrointest Surg 10 : 6 ~ 11
[학술지(정기간행물)] - Lee H / 2015 / Hepatectomy vs radiofrequency ablation for colorectal liver metastasis : a propensity score analysis / World J Gastroenterol 21 : 3300 ~ 3307
[학술지(정기간행물)] - Copher GH / 1928 / "Streamline"phenomena in the portal vein and selective distribution of portal blood in the liver / Arch Surg 17 : 408 ~ 419
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UCI(KEPA) : I410-ECN-0101-2018-514-000801132