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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 242 - 250 (9page)
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Purpose Colorectal cancer patients with liver-confined metastases are classified as stage IV, but theirprognoses can differ from metastases at other sites. In this study, we suggest a novelmethod for risk stratification using clinically effective factors.
Materials and MethodsData on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989and 2010 were analyzed. This analysis was based on principal component analysis (PCA).
ResultsThe survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio,1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval(DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups accordingto PCA score using significantly affected factors, they showed significantly different survivalpatterns (p < 0.001).
ConclusionThe PCA scoring system based on CEA level, distribution of liver metastasis, and DFI maybe useful for preoperatively determining prognoses in order to assist in clinical decisionmakingand designing future clinical trials for CLM treatment.
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참고문헌 (24)
참고문헌 신청
Adam R / 2001 / Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal / Ann Surg Oncol 8 : 347 ~ 353
Adam R / 2009 / Accomplishments in 2008 in the management of curable metastatic colorectal cancer / Gastrointest Cancer Res 3 (5 Suppl 2) : S15 ~ 22
Ambiru S / 1999 / Hepatic resection for colorectal metastases : analysis of prognostic factors / Dis Colon Rectum 42 : 632 ~ 639
Arru M / 2008 / Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic colorectal cancer / World J Surg 32 : 93 ~ 103
Choti MA / 2002 / Trends in long-term survival following liver resection for hepatic colorectal metastases / Ann Surg 235 : 759 ~ 766
Adam R / 2009 / Accomplishments in 2008 in the management of curable metastatic colorectal cancer / Gastrointest Cancer Res 3 (5 Suppl 2) : S15 ~ 22
Ambiru S / 1999 / Hepatic resection for colorectal metastases : analysis of prognostic factors / Dis Colon Rectum 42 : 632 ~ 639
Arru M / 2008 / Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic colorectal cancer / World J Surg 32 : 93 ~ 103
Choti MA / 2002 / Trends in long-term survival following liver resection for hepatic colorectal metastases / Ann Surg 235 : 759 ~ 766
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