지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.2
- 발행연도
- 2017.2
- 수록면
- 97 - 104 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Inhibitory effect of paclitaxel on neointimal hyperplasia after open cutdown has not been elucidated.
Methods: For the control group (n = 16), silicone 2.7-Fr catheters were placed via the right external jugular vein with the cutdown method. For the treatment group (n = 16), a mixture of 0.65 mg of paclitaxel and 1 mL of fibrin glue was infiltrated around the exposed vein after cutdown. After scheduled intervals (1, 2, 4, and 8 weeks), the vein segment was harvested and morphometric analysis was performed on cross-sections.
Results: Proliferation of smooth muscle cell (SMC) was strongly suppressed in the treatment group, and the ratio of neointima to vein wall was significantly reduced in the treatment group (8 weeks; 0.63 ± 0.08 vs. 0.2 ± 0.08, P < 0.05). Luminal patency was significantly more preserved in the treatment group, and the luminal area was significantly wider in the paclitaxel-treated group compared to the control group (8 weeks; 1.91 ± 0.43 mm2 vs. 5.1 ± 0.43 mm2, P < 0.05). Mean SMC counts measured at 1 and 2 weeks after cutdown were significantly lower in the treatment group (2 weeks; 115 ± 22 vs. 62 ± 22). Paclitaxel was undetectable in systemic circulation (<10 ng/mL).
Conclusion: Sustained perivascular delivery of paclitaxel with fibrin glue was effective in inhibiting neointimal hyperplasia in rat jugular vein after open cutdown.
Methods: For the control group (n = 16), silicone 2.7-Fr catheters were placed via the right external jugular vein with the cutdown method. For the treatment group (n = 16), a mixture of 0.65 mg of paclitaxel and 1 mL of fibrin glue was infiltrated around the exposed vein after cutdown. After scheduled intervals (1, 2, 4, and 8 weeks), the vein segment was harvested and morphometric analysis was performed on cross-sections.
Results: Proliferation of smooth muscle cell (SMC) was strongly suppressed in the treatment group, and the ratio of neointima to vein wall was significantly reduced in the treatment group (8 weeks; 0.63 ± 0.08 vs. 0.2 ± 0.08, P < 0.05). Luminal patency was significantly more preserved in the treatment group, and the luminal area was significantly wider in the paclitaxel-treated group compared to the control group (8 weeks; 1.91 ± 0.43 mm2 vs. 5.1 ± 0.43 mm2, P < 0.05). Mean SMC counts measured at 1 and 2 weeks after cutdown were significantly lower in the treatment group (2 weeks; 115 ± 22 vs. 62 ± 22). Paclitaxel was undetectable in systemic circulation (<10 ng/mL).
Conclusion: Sustained perivascular delivery of paclitaxel with fibrin glue was effective in inhibiting neointimal hyperplasia in rat jugular vein after open cutdown.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Hong SM / 2013 / Central venous cutdown in neonates : feasibility as a bedside procedure without general anesthesia / J Pediatr Surg 48 : 1722 ~ 1726
[학술지(정기간행물)] - Kim MJ / 2010 / Internal jugular vein deformities after central venous catheterisation in neonates : evaluation by Doppler ultrasound / J Paediatr Child Health 46 : 154 ~ 158
[학술지(정기간행물)] - Willetts IE / 2000 / Venous patency after open central-venous cannulation / Pediatr Surg Int 16 : 411 ~ 413
[학술지(정기간행물)] - Kim S / 2015 / Histological changes of the unligated vein wall adjacent to the central venous catheter after open cutdown in rats / J Pediatr Surg 50 : 1928 ~ 1932
[학술지(정기간행물)] - Dake MD / 2011 / Polymer-free paclitaxel-coated Zilver PTX Stents--evaluation of pharmacokinetics and comparative safety in porcine arteries / J Vasc Interv Radiol 22 : 603 ~ 610
[학술지(정기간행물)] - Kim MJ / 2010 / Internal jugular vein deformities after central venous catheterisation in neonates : evaluation by Doppler ultrasound / J Paediatr Child Health 46 : 154 ~ 158
[학술지(정기간행물)] - Willetts IE / 2000 / Venous patency after open central-venous cannulation / Pediatr Surg Int 16 : 411 ~ 413
[학술지(정기간행물)] - Kim S / 2015 / Histological changes of the unligated vein wall adjacent to the central venous catheter after open cutdown in rats / J Pediatr Surg 50 : 1928 ~ 1932
[학술지(정기간행물)] - Dake MD / 2011 / Polymer-free paclitaxel-coated Zilver PTX Stents--evaluation of pharmacokinetics and comparative safety in porcine arteries / J Vasc Interv Radiol 22 : 603 ~ 610
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UCI(KEPA) : I410-ECN-0101-2017-514-002372285