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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 21 - 29 (9page)
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초록· 키워드
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Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction of chemical carcinogens. Histopathological findings showed mild hyperplasia to epithelial vacuolar change, and high grade dysplasia. Squamous metaplasia was observed in the S. haematobium eggs+NDMA group at week 12 but not in other groups. Immunohistochemistry revealed significantly high expression of Ki-67 in urothelial epithelial cells of the S. haematobium eggs+BBN group at week 20. The qRT-PCR showed high expression of p53 gene in S. haematobium eggs group at week 4 and S. haematobium eggs+BBN group at week 20. E-cadherin and vimentin showed contrasting expression in S. haematobium eggs+BBN group. Such inverse expression of E-cadherin and vimentin may indicate epithelial mesenchymal transition in the UB tissue. In conclusion, S. haematobium eggs and nitrosamines may transform UB cells into squamous metaplasia and dysplasia in correlation with increased expression of Ki-67. Marked decrease in E-cadherin and increase in p53 and vimentin expressions may support the transformation. The present study introduces a promising modified animal model for UB cancer study using S. haematobium eggs.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
[학술지(정기간행물)] - IARC Working Group on the Evaluation of Carcinogenic Risks to Humans / 2012 / Biological agents. Volume 100 B. A review of human carcinogens / IARC Monogr Eval Carcinog Risks Hum 100 (Pt B) : 1 ~ 441
[학술지(정기간행물)] - Rausch S / 2012 / Nonbilharzial squamous cell carcinoma and transitional cell carcinoma with squamous differentiation of the lower and upper urinary tract / Urol Ann 4 : 14 ~ 18
[학술지(정기간행물)] - Mostafa HM / 1999 / Relationship between schistosomiasis and bladder cancer / Clin Microbiol Rev 12 : 97 ~ 111
[학술지(정기간행물)] - Shirahama T / 2001 / Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder / Clin Cancer Res 7 : 558 ~ 561
[학술지(정기간행물)] - Heyns CF / 2008 / Bladder cancer in Africa / Can J Urol 15 : 3899 ~ 3908
[학술지(정기간행물)] - Rausch S / 2012 / Nonbilharzial squamous cell carcinoma and transitional cell carcinoma with squamous differentiation of the lower and upper urinary tract / Urol Ann 4 : 14 ~ 18
[학술지(정기간행물)] - Mostafa HM / 1999 / Relationship between schistosomiasis and bladder cancer / Clin Microbiol Rev 12 : 97 ~ 111
[학술지(정기간행물)] - Shirahama T / 2001 / Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder / Clin Cancer Res 7 : 558 ~ 561
[학술지(정기간행물)] - Heyns CF / 2008 / Bladder cancer in Africa / Can J Urol 15 : 3899 ~ 3908
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UCI(KEPA) : I410-ECN-0101-2017-513-002242065