개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices
Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.31 KCI Accredited Journals SCOPUS
- 발행연도
- 2016.12
- 수록면
- 153 - 161 (9page)
이용수
Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices
초록· 키워드
오류제보하기
Objectives Korea’s Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances are introduced annually across the globe, the extent of animal testing requirement could be overwhelming unless regulators and companies work proactively to institute and enforce global best practices to replace, reduce or refine animal use. In this review, the way to reduce the animal use for K-REACH is discussed.
Methods Background of the enforcement of the K-REACH and its details was reviewed along with the papers and regulatory documents regarding the limitation of animal experiments and its alternatives in order to discuss the regulatory adoption of alternative tests.
Results Depending on the tonnage of the chemical used, the data required ranges from acute and other short-term studies for a single exposure route to testing via multiple exposure routes and costly, longer-term studies such as a full two-generation reproducibility toxicity. The European Registration, Evaluation, Authorization and Restriction of Chemicals regulation provides for mandatory sharing of vertebrate test data to avoid unnecessary duplication of animal use and test costs, and obligation to revise data requirements and test guidelines “as soon as possible” after relevant, validated replacement, reduction or refinement (3R) methods become available. Furthermore, the Organization for Economic Cooperation and Development actively accepts alternative animal tests and 3R to chemical toxicity tests.
Conclusions Alternative tests which are more ethical and efficient than animal experiments should be widely used to assess the toxicity of chemicals for K-REACH registration. The relevant regulatory agencies will have to make efforts to actively adopt and uptake new alternative tests and 3R to K-REACH.
Methods Background of the enforcement of the K-REACH and its details was reviewed along with the papers and regulatory documents regarding the limitation of animal experiments and its alternatives in order to discuss the regulatory adoption of alternative tests.
Results Depending on the tonnage of the chemical used, the data required ranges from acute and other short-term studies for a single exposure route to testing via multiple exposure routes and costly, longer-term studies such as a full two-generation reproducibility toxicity. The European Registration, Evaluation, Authorization and Restriction of Chemicals regulation provides for mandatory sharing of vertebrate test data to avoid unnecessary duplication of animal use and test costs, and obligation to revise data requirements and test guidelines “as soon as possible” after relevant, validated replacement, reduction or refinement (3R) methods become available. Furthermore, the Organization for Economic Cooperation and Development actively accepts alternative animal tests and 3R to chemical toxicity tests.
Conclusions Alternative tests which are more ethical and efficient than animal experiments should be widely used to assess the toxicity of chemicals for K-REACH registration. The relevant regulatory agencies will have to make efforts to actively adopt and uptake new alternative tests and 3R to K-REACH.
목차
Introduction
Act on the Registration and Evaluation of Chemicals: Data Requirements, Test Guidelines and Skyrocketing Animal Use
Limitation and Problems of Conventional Animal Experiments
New Methods as Replacements for Conventional Animal Tests
Development of Non-animal Based Alternatives and Their Adoption byRegulatory Science
Pros and Cons of In Vitro Alternatives to Animal Tests
Barriers to Acceptance of Non-animal Based Alternatives in Act on the Registration and Evaluation of Chemicals and Recommendations
Conclusion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Replacement techniques to reduce animal experiments in drug and nanoparticle development
Journal of Pharmaceutical Investigation
2020 .01
-
Existing test data for the Act on Registration & Evaluation, etc. of Chemical Substances
Environmental Analysis Health and Toxicology
2015 .12
-
A Study on the development of animal practice guidelines for elementary, middle and high schools in Republic of Korea
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Animal testing ethics & life
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Read-Across(상관성 방식)을 활용한 화평법 규제 대응 방안 마련
환경독성보건학회 심포지엄 및 학술대회
2021 .10
-
New animal models and different animal models
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Understanding the animal experiment regulatory system
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Appropriate Methodologies in Animal Research Using Small Animal Models
대한외과학회 학술대회 초록집
2018 .11
-
A COVID-19 pandemic: the survey for animal users and care staff in Korea
한국실험동물학회 학술발표대회 논문집
2022 .07
-
[S2-4] Advancing the 3Rs principle: scientific and ethical considerations for responsible reuse of laboratory animals
한국실험동물학회 학술발표대회 논문집
2024 .07
-
Improvement of the registration system of animal research facility
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Animal welfare in the production of laboratory animals
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Development of LMO management program for experiment and research
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Statistics of Using Experimental Animal in Korea
한국실험동물학회 학술발표대회 논문집
2016 .08
-
화평법에서의 화학물질 등록을 위한 신뢰성 있는 상관성방식 활용 방안 연구
환경독성보건학회 심포지엄 및 학술대회
2022 .05
-
Current status of utilization of animal alternative tests in new drugs and medical devices
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Mental stress of animal researchers and ways to relieve it
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Role of laboratory animal technician for reliable animal testing
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Current operational issues of the Institutional Animal Care and Use Committee in Korea and suggestions for improvement
한국실험동물학회 학술발표대회 논문집
2022 .07
-
[S2-1] Considerations for end-experimental animals
한국실험동물학회 학술발표대회 논문집
2024 .07
이 논문의 저자 정보
이 논문과 함께 이용한 논문
2010년~2014년 국민건강영양조사 자료를 이용한 성인의 나트륨 섭취와 비만과의 관련성
천세영
,
왕혜원
,
이화정
외 3명
Journal of Nutrition and Health
2017
.02
자일로바이오스를 함유한 설탕이 젊은 여성의 변비 개선에 미치는 효과
이정숙
,
김아름
,
남혜경
외 3명
Journal of Nutrition and Health
2017
.02
한반도 남동부에 분포하는 A-형 화강암의 암석학적 특성과 성인
명보라
,
박종규
,
박수민
외 2명
대한지질학회 학술대회
2016
.10
춘천 중도 현생 하천 퇴적층의 퇴적작용과 퇴적환경 해석
김재우
,
정대교
,
신승원
대한지질학회 학술대회
2016
.10
가평 지역에서 산출되는 각섬석 감람암과 인접한 각섬암 내부의 감람석과 각섬석의 격자 선호방향에 대한 연구
이재석
,
정해명
대한지질학회 학술대회
2016
.10
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-539-002198253