지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 326 - 329 (4page)
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초록· 키워드
오류제보하기
Deoxyribonucleotides (dNTPs) are important for the efficient growth of DNA viruses. Therefore, many DNA viruses have strategies for the upregulation of cellular dNTP levels. Both α- and γ-herpesviruses encode functional homologs of cellular dNTP anabolic enzymes, including the class I ribonucleotide reductase (RNR) large (R1) and small (R2) subunits, whereas β-herpesviruses modulate host cells to induce genes that increase dNTP levels. Interestingly, β-herpesviruses still express the nonfunctional RNR R1 subunit. However, it is not clear why β-herpesviruses still carry inactive R1 homologs. Recently, the R1 homologs of herpesviruses have been shown to inhibit innate immune signaling pathways. In particular, both functional and nonfunctional R1 homologs target receptor-interacting protein kinase 1 (RIP1) and inhibit RIP1-mediated signaling pathways to promote viral replication. Here, we summarize recent findings on the activity of herpesviral R1 homologs and discuss their roles in the regulation of innate immune signaling pathways.
목차
INTRODUCTION
CLOSING REMARKS
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Jordan A / 1998 / Ribonucleotide reductases / Annu Rev Biochem 67 : 71 ~ 98
[학술지(정기간행물)] - Lembo D / 2009 / Tinkering with a viral ribonucleotide reductase / Trends Biochem Sci 34 : 25 ~ 32
[학술지(정기간행물)] - Nordlund P / 2006 / Ribonucleotide reductases / Annu Rev Biochem 75 : 681 ~ 706
[학술지(정기간행물)] - Jacobson JG / 1989 / A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells / Virology 173 : 276 ~ 283
[학술지(정기간행물)] - Idowu AD / 1992 / Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo / Antiviral Res 17 : 145 ~ 156
[학술지(정기간행물)] - Lembo D / 2009 / Tinkering with a viral ribonucleotide reductase / Trends Biochem Sci 34 : 25 ~ 32
[학술지(정기간행물)] - Nordlund P / 2006 / Ribonucleotide reductases / Annu Rev Biochem 75 : 681 ~ 706
[학술지(정기간행물)] - Jacobson JG / 1989 / A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells / Virology 173 : 276 ~ 283
[학술지(정기간행물)] - Idowu AD / 1992 / Deletion of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo / Antiviral Res 17 : 145 ~ 156
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UCI(KEPA) : I410-ECN-0101-2017-475-001976705