지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 335 - 342 (8page)
이용수
초록· 키워드
오류제보하기
According to World Health Organization, more than 200 million people suffer with chronic hepatitis caused by Hepatitis B virus (HBV) infection worldwide. Chronic hepatitis B causes various complications including liver cirrhosis and hepatocellular carcinoma and approximately 0.5~4.2 million deaths occur annually due to HBV infection. Current therapies such as antivirals and vaccine are often hampered by drug intolerance, side effects, and long-time medication, therefore, the development of powerful anti-HBV drugs is demanded. Recently, sodium taurocholate co-transporting polypeptide (NTCP) receptor was revealed to play a pivotal role in HBV entry into hepatocytes. Cell lines transfected with NTCP receptor enables to analyze HBV life cycle by inducing HBV infection stably, but in vivo models still have some limitations such as high costs, restrictive differentiation, and unveiled cofactors related to human NTCP. Therefore, it requires well-established in vivo models to develop and evaluate novel therapeutic agents targeting NTCP receptor, and viral entry inhibitors that inhibit the early step of viral infection are potent sufficient to substitute for existing antivirals.
목차
INTRODUCTION
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - / 2013 / Global Burden of Disease Study 2010 outlines present and future health priorities, both nationally and internationally / Br J Hosp Med (Lond) 74 : 71 ~
[학술지(정기간행물)] - Glebe D / 2005 / Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes / Gastroenterol 129 : 234 ~ 245
[학술지(정기간행물)] - Watashi K / 2014 / NTCP and beyond : opening the door to unveil hepatitis B virus entry / Int J Mol Sci 15 : 2892 ~ 2905
[학술지(정기간행물)] - Dienstag JL / 2008 / Hepatitis B virus infection / N Engl J Med 359 : 1486 ~ 1500
[학술지(정기간행물)] - Iwamoto M / 2014 / Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP / Biochem Biophys Res Commun 443 : 808 ~ 813
[학술지(정기간행물)] - Glebe D / 2005 / Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes / Gastroenterol 129 : 234 ~ 245
[학술지(정기간행물)] - Watashi K / 2014 / NTCP and beyond : opening the door to unveil hepatitis B virus entry / Int J Mol Sci 15 : 2892 ~ 2905
[학술지(정기간행물)] - Dienstag JL / 2008 / Hepatitis B virus infection / N Engl J Med 359 : 1486 ~ 1500
[학술지(정기간행물)] - Iwamoto M / 2014 / Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP / Biochem Biophys Res Commun 443 : 808 ~ 813
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UCI(KEPA) : I410-ECN-0101-2017-475-001976689