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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 68 - 76 (9page)
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초록· 키워드
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The lymphatic vasculature has been regarded as a passive conduit for interstitial fluid and responsible for the
absorption of macromolecules such as proteins or lipids and transport of nutrients from food. However, emerging
data show that the lymphatic vasculature system plays an important role in immune modulation. One of its major
roles is to coordinate antigen transport and immune-cell trafficking from peripheral tissues to secondary lymphoid
organs, lymph nodes. This perspective was recently updated with the notion that the interaction between lymphatic
endothelial cells and leukocytes controls the immune-cell migration and immune responses by regulating lymphatic
flow and various secreted molecules such as chemokines and cytokines. In this review, we introduce the lymphatic
vasculature networks and genetic transgenic models for research on the lymphatic vasculature system. Next, we
discuss the contribution of lymphatic endothelial cells to the control of immune-cell trafficking and to maintenance
of peripheral tolerance. Finally, the physiological roles and features of the lymphatic vasculature system are further
discussed regarding inflammation-induced lymphangiogenesis in a pathological condition, especially in mucosal
tissues such as the gastrointestinal tract and respiratory tract.
목차
INTRODUCTION
Lymphatics in the circulatory system
Lymphatic vessels from peripheral tissues to lymph nodes
The role of lymphatics in the regulation of tolerance
The role of lymphatics in inflammation
Lymphatic vessels in mucosal tissues
Conclusions
REFERENCES
참고문헌 (41)
참고문헌 신청
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UCI(KEPA) : I410-ECN-0101-2017-517-002233620