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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 139 - 145 (7page)
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In this paper, we propose to evaluate the effect of Resistin-like molecule alpha (Retnla) on the expression of transporters involved in modulating concentrations of peripheral cholesterol and plasma high-density lipoprotein (HDL) cholesterol. High levels of blood cholesterol are a well-recognized risk factor for atherosclerosis and are eliminated via the process of reverse cholesterol transport (RCT). We recently showed that Retnla ameliorates hypercholesterolemia and atherosclerosis by increasing biliary cholesterol secretion, the final step of the process, in low-density lipoprotein receptor-deficient mice. However, the role of Retnla in HDL-mediated cholesterol efflux, initial step of RCT pathway, is not yet clear. To identify cholesterol transport genes regulated by Retnla, we performed an extensive microarray-based gene expression screen using livers from Retnla-overexpressing (Tg) mice and control animals. The most significant change in Retnla-Tg mice was an upregulation of ATP-binding cassette sub-family G member 4 (Abcg4) transport and was validated using quantitative RT-PCR. The validated gene was also induced by treatment of purified Retnla protein in RAW 264.7 cells incubated with acetylated low-density lipoprotein and Hepa1c1c7 cells. Taken together, these results indicates that Retnla might also accelerate initial step of RCT pathway, suggesting therapeutic value of Retnla in the treatment of hypercholesterolemia and atherosclerosis.
목차
Abstract
Ⅰ. Introduction
Ⅱ. Related Works
Ⅲ. Methodology
Ⅳ. Results
Ⅴ. Conclusions and Discussion
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - P. Libby / 2011 / Progress and challenges in translating the biology of atherosclerosis / Nature 473 (7347) : 317 ~ 325
[학술지(정기간행물)] - F. Schaftenaar / 2016 / Atherosclerosis : the interplay between lipids and immune cells / Current Opinion in Lipidology 27 (3) : 209 ~ 215
[학술지(정기간행물)] - S. J. Rho / 2015 / Prevalence of hypercholesterolemia among adults over 30 years old in Korea, 2009-2013 / Public Health Weekly Report 8 (36) : 857 ~ 860
[학술지(정기간행물)] - Y. A. Kim / 2014 / Status of cholesterol level among adults in Korea, 2008-2011 / Public Health Weekly Report 7 (35) : 773 ~ 776
[학술지(정기간행물)] - S. L. Pinkosky / 2016 / Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis / Nature Communications 7 : 13457 ~
[학술지(정기간행물)] - F. Schaftenaar / 2016 / Atherosclerosis : the interplay between lipids and immune cells / Current Opinion in Lipidology 27 (3) : 209 ~ 215
[학술지(정기간행물)] - S. J. Rho / 2015 / Prevalence of hypercholesterolemia among adults over 30 years old in Korea, 2009-2013 / Public Health Weekly Report 8 (36) : 857 ~ 860
[학술지(정기간행물)] - Y. A. Kim / 2014 / Status of cholesterol level among adults in Korea, 2008-2011 / Public Health Weekly Report 7 (35) : 773 ~ 776
[학술지(정기간행물)] - S. L. Pinkosky / 2016 / Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis / Nature Communications 7 : 13457 ~
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UCI(KEPA) : I410-ECN-0101-2017-004-001969874