지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 344 - 357 (14page)
이용수
초록· 키워드
오류제보하기
Lymphocyte subpopulations producing cytokines and exerting regulatory functions represent key immune elements. Given their reciprocal interdependency lymphocyte subpopulations are usually assayed as diagnostic panels, rather than single biomarkers for specialist clinical use. This retrospective analysis on lymphocyte subpopulations, analyzed over the last few years in an outpatient laboratory in Northeast Italy, contributes to the establishment of reference values for several regulatory lymphocytes currently lacking such reference ranges for the general population. Mean values and ranges in a sample of Caucasian patients (mean age 42±8,5 years), were provided for Th1, Th2, Th17, Th-reg, Tc-reg, Tc-CD57+ and B1 lymphocytes. The results are consistent with what is found in literature for the single subtypes and are: Th1 157.8±60.3/ml (7.3%±2.9); Th2 118.2±52.2/ml (5.4%±2.5); Th17 221.6±90.2/ml (10.5%±4.4); Th-reg 15.1±10.2/ml (0.7%±0.4); Tc-reg 5.8±4.7/ml (0.3%±0.2); Tc-CD57+ 103.7±114.1/ml (4.6%±4.7); B1 33.7±22.8/ml (1.5%±0.9); (Values are mean±SD). The results show that despite their variability, mean values are rather consistent in all age or sex groups and can be used as laboratory internal reference for this regulatory panel. Adding regulatory cells to lymphocyte subpopulations panels allows a more complete view of the state of the subject’s immune network balance, thus improving the personalization and the “actionability” of diagnostic data in a systems medicine perspective.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (111)
참고문헌 신청
Tosato, F / 2013 / Biological variability of lymphocyte subsets of human adults / blood. Clin. Chim. Acta 424:159~163
최종범 / 2014 / Reference Values for Peripheral Blood Lymphocyte Subsets in a Healthy Korean Population / Immune Network 14(6):289~295
McCoy, J. P. Jr / 1999 / Current practices in clinical flow cytometry. A practice survey by the American Society of Clinical Pathologists / Am. J. Clin. Pathol 111:161~168
Yanaba, K / 2008 / B-lymphocyte contributions to human autoimmune disease / Immunol. Rev 223:284~299
Doreau, A / 2009 / Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus / Nat. Immunol 10:778~785
최종범 / 2014 / Reference Values for Peripheral Blood Lymphocyte Subsets in a Healthy Korean Population / Immune Network 14(6):289~295
McCoy, J. P. Jr / 1999 / Current practices in clinical flow cytometry. A practice survey by the American Society of Clinical Pathologists / Am. J. Clin. Pathol 111:161~168
Yanaba, K / 2008 / B-lymphocyte contributions to human autoimmune disease / Immunol. Rev 223:284~299
Doreau, A / 2009 / Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus / Nat. Immunol 10:778~785
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UCI(KEPA) : I410-ECN-0101-2017-517-001848987