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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 13 - 26 (14page)
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Objectives: Inflammatory bowel disease (IBD) is chronic inflammatory disorders of the intestines. Due to limitation of conventional treatment including steroids, herbal medicines have emerged as possible therapeutic options for IBD. The purpose of the current study was to investigate the therapeutic and prophylactic effects and mechanisms of Zostera Marina water extract (ZME) on DSS-induced colitis.
Methods: Colitis was induced by DSS in Balb/c mice. In pre-treatment setting, ZME was administered 7 days before DSS treatment and in co-treatment setting, ZME was simultaneously administrated with DSS treatment. In both settings, ZME 100, 300 and 1000 mg/kg were orally administered twice a day, respectively. Mice weight and clinical findings were measured daily. Colon length, macroscopic findings and histological damages of colon mucosa were assessed at the end of experiments. The levels of cytokines including TNF-α, IFN-γ, IL-1β, IL-6, IL-10 and IL-17 were measured by Biometric Multiplex Cytokine Profiling method.
Results: In a dose dependent manner, ZME significantly inhibited the colon shortening, and improved macroscopic score and histological score. However, there were insignificant changes on inhibition of weight loss and improvement of clinical score. There were no significant differences of effects between co-treatment and pre-treatment settings. ZME 300 and 1000 mg/kg groups significantly inhibited IFN-γ. Only ZME 1000 mg/kg group significantly inhibited TNF-α, IL-1β and IL-6.
Conclusions: The current results show the possibility of therapeutic use and its prophylactic application of ZME on inflammatory bowel diseases. Future studies for targeted mechanisms of ZME are needed.
Methods: Colitis was induced by DSS in Balb/c mice. In pre-treatment setting, ZME was administered 7 days before DSS treatment and in co-treatment setting, ZME was simultaneously administrated with DSS treatment. In both settings, ZME 100, 300 and 1000 mg/kg were orally administered twice a day, respectively. Mice weight and clinical findings were measured daily. Colon length, macroscopic findings and histological damages of colon mucosa were assessed at the end of experiments. The levels of cytokines including TNF-α, IFN-γ, IL-1β, IL-6, IL-10 and IL-17 were measured by Biometric Multiplex Cytokine Profiling method.
Results: In a dose dependent manner, ZME significantly inhibited the colon shortening, and improved macroscopic score and histological score. However, there were insignificant changes on inhibition of weight loss and improvement of clinical score. There were no significant differences of effects between co-treatment and pre-treatment settings. ZME 300 and 1000 mg/kg groups significantly inhibited IFN-γ. Only ZME 1000 mg/kg group significantly inhibited TNF-α, IL-1β and IL-6.
Conclusions: The current results show the possibility of therapeutic use and its prophylactic application of ZME on inflammatory bowel diseases. Future studies for targeted mechanisms of ZME are needed.
목차
서론
실험재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (49)
참고문헌 신청
[학술지(정기간행물)] - 한동수 / 2002 / 다량의 복수가 주 증상으로 나타난 POEMS 증후군 1예 / 대한소화기학회지 40 (3) : 1 ~ 1
[기타자료] - Department of Internal Medicine, Medical School, Seoul National University / 2002 / Guideline of Internal Medicine / Korea Medicine Publication : 51 ~ 53
[단행본] - Kim JY / 2000 / Gastrointestinal Disorders / Iljogak : 258 ~ 276
[학술지(정기간행물)] - 박재우 / 2011 / Protective effects of Ulmus macrocarpa on experimental colitis mice models / Oriental Pharmacy and Experimental Medicine 11 (2) : 107 ~ 112
[학술지(정기간행물)] - 서검석 / 2009 / 궤양성 대장염의 병태생리 - 유전 및 면역 관련성 / 대한내과학회지 76 (6) : 643 ~ 648
[기타자료] - Department of Internal Medicine, Medical School, Seoul National University / 2002 / Guideline of Internal Medicine / Korea Medicine Publication : 51 ~ 53
[단행본] - Kim JY / 2000 / Gastrointestinal Disorders / Iljogak : 258 ~ 276
[학술지(정기간행물)] - 박재우 / 2011 / Protective effects of Ulmus macrocarpa on experimental colitis mice models / Oriental Pharmacy and Experimental Medicine 11 (2) : 107 ~ 112
[학술지(정기간행물)] - 서검석 / 2009 / 궤양성 대장염의 병태생리 - 유전 및 면역 관련성 / 대한내과학회지 76 (6) : 643 ~ 648
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UCI(KEPA) : I410-ECN-0101-2017-519-001862512