지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.3
- 발행연도
- 2016.9
- 수록면
- 208 - 220 (13page)
이용수
초록· 키워드
오류제보하기
The aim of this study was to investigate the protective effects of juice powders from sweet orange [Citrus sinensis (L.) Osbeck], unshiu mikan (Citrus unshiu Marcow), and mini tomato (Solanum lycopersicum L.), and their major flavonoids, hesperidin, narirutin, and rutin in tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in HepG2 cells. The increased reactive oxygen species and decreased glutathione levels observed in t-BHP-treated HepG2 cells were ameliorated by pretreatment with juice powders, indicating that the hepatoprotective effects of juice powders and their major flavonoids are mediated by induction of cellular defense against oxidative stress. Moreover, pretreatment with juice powders up-regulated phase-II genes such as heme oxygenase-1 (HO-1), thereby preventing cellular damage and the resultant increase in HO-1 expression. The high-performance liquid chromatography profiles of the juice powders confirmed that hesperidin, narirutin, and rutin were the key flavonoids present. Our results suggest that these fruit juice powders and their major flavonoids provide a significant cytoprotective effect against oxidative stress, which is most likely due to the flavonoid-related bioactive compounds present, leading to the normal redox status of cells. Therefore, these fruit juice powders could be advantageous as bioactive sources for the prevention of oxidative injury in hepatoma cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (63)
참고문헌 신청
[학술지(정기간행물)] - Breimer LH / 1990 / Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis : the role of DNA base damage / Mol Carcinog 3 : 188 ~ 197
[학술지(정기간행물)] - Rushmore TH / 2002 / Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes / Curr Drug Metab 3 : 481 ~ 490
[학술지(정기간행물)] - Kapitulnik J / 2004 / Bilirubin : an endogenous product of heme degradation with both cytotoxic and cytoprotective properties / Mol Pharmacol 66 : 773 ~ 779
[학술지(정기간행물)] - Alam J / 2003 / Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway / Curr Pharm Des 9 : 2499 ~ 2511
[학술지(정기간행물)] - Morse D / 2002 / Heme oxygenase-1 : the"emerging molecule"has arrived / Am J Respir Cell Mol Biol 27 : 8 ~ 16
[학술지(정기간행물)] - Rushmore TH / 2002 / Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes / Curr Drug Metab 3 : 481 ~ 490
[학술지(정기간행물)] - Kapitulnik J / 2004 / Bilirubin : an endogenous product of heme degradation with both cytotoxic and cytoprotective properties / Mol Pharmacol 66 : 773 ~ 779
[학술지(정기간행물)] - Alam J / 2003 / Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway / Curr Pharm Des 9 : 2499 ~ 2511
[학술지(정기간행물)] - Morse D / 2002 / Heme oxygenase-1 : the"emerging molecule"has arrived / Am J Respir Cell Mol Biol 27 : 8 ~ 16
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Organic acid and sugar contents in different domestic fruit juices
Korean Journal of Agricultural Science
2016 .12
-
Development and Quality Characteristics of Mixed Juice to Promote Consumption of Aronia Juice
한국식품영양과학회 학술대회발표집
2018 .10
-
Functional juice and quality characteristics using fruits and vegetables
한국식품영양과학회 학술대회발표집
2022 .10
-
Effect of Mixed Fruit and Vegetable Juice on Alcohol Hangovers in Healthy Adults
Preventive Nutrition and Food Science
2018 .03
-
저속압착방식으로 착즙한 오디주스의 항산화 및 항염증 효과
한국식품영양과학회지
2020 .05
-
Antioxidant properties of commercial fruit juices and vinegars
한국식품영양과학회 학술대회발표집
2015 .08
-
Comparative Study on Qualities of Fresh Paprika Juices Prepared by Household High-Speed Blender and Low-Speed Juicer
한국식품영양과학회 학술대회발표집
2021 .10
-
Field Study on Major Foodborne Bacteria at the Fruit Juice Processing Stage
한국식품영양과학회 학술대회발표집
2023 .10
-
저속 압착 방식의 착즙기와 고속 파쇄 방식의 블랜더를 사용한 주스의 품질 변화에 대한 연구
한국식품영양학회지
2017 .06
-
콩즙 처리에 따른 한지의 물성 및 표면 특성 연구
펄프·종이기술
2021 .08
-
Quality Characteristics of Commercially Available Pear Juices and Farm-processed Pear Juices
한국식품영양과학회 학술대회발표집
2021 .10
-
Effect of Extraction Method on Physiochemical, Bioactive Compounds, and Antioxidant Activities of Juices from Various Fruits and Vegetables
한국식품영양과학회 학술대회발표집
2015 .08
-
Monitoring Residual Pesticides in Fruit-Vegetable Juices
한국농약과학회 학술발표대회 논문집
2020 .11
-
Physicochemical Properties, Total Phenolic, Flavonoid content and Antioxidant Activities of Commercial Orange and Grapefruit Juices
한국식품영양과학회 학술대회발표집
2018 .10
-
Hepatoprotective Effect of Fresh Grape Juice Prepared by a Low-Speed Masticating Juicer in db/db Mice
Preventive Nutrition and Food Science
2019 .03
-
Lactobacillus plantarum MKHA15와 Leuconostoc mesenteroides MKSR을 첨가한 발효 채소 주스의 특성
대한영양사협회 학술지
2019 .01
-
Physicochemical Properties and Antioxidant Activity of Commercial Fruit and Vegetable Juice
한국식품영양과학회 학술대회발표집
2018 .10
-
Monitoring on Pesticide Residues of Fruit-vegetable juices
한국식품영양과학회 학술대회발표집
2020 .10
-
Physico-chemical Characteristics of Jelly According to the Addition Amount of Immature Citrus unshiu Juice
한국식품영양과학회 학술대회발표집
2020 .10
-
유동 초고압 공정을 이용한 딸기 주스의 미생물 안정성 향상 및 품질보존
한국식품과학회지
2015 .08
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-594-001391884