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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 167 - 172 (6page)
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초록· 키워드
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In the present study we evaluated the anti-inflammatory potential of 3-hydroxy-4,7-megastigmadien-9-one (Comp) isolated from Ulva pertusa Kjellman, in LPS-stimulated bone marrow-derived dendritic cells (BMDCs). Comp treatment exhibited strong dose dependent inhibition of IL-12 p40 and IL-6 cytokine production with IC<SUB>50</SUB> values of 7.85 ± 0.32 and 7.86 ± 0.18, respectively in LPS-stimulated BMDCs. Treatment of Comp inhibited MAPKs and NF-κB pathways in LPS-stimulated BMDCs by inhibiting the phosphorylation of ERK1/2, JNK1/2, p38 and IκB. Thus, these results suggest that Comp have a significant anti-inflammatory property and affirm further studies concerning the potentials of Comp for medicinal use.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Katoh H / 2013 / CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis / Cancer Cell 24 : 631 ~ 644
[학술지(정기간행물)] - Uronis JM / 2009 / Modulation of the intestinal microbiota alters colitis associated colorectal cancer susceptibility / PLoS One 4 : e6026 ~
[학술지(정기간행물)] - Honstettre A / 2004 / Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through tolllike receptor 4 / J Immunol 172 : 3695 ~ 3703
[학술지(정기간행물)] - Rakoff-Nahoum S / 2006 / Role of tolllike receptor in spontaneous commensal-dependent colitis / Immunity 25 : 319 ~ 329
[학술지(정기간행물)] - Rakoff-Nahoum S / 2004 / Recognition of commensal microflora by toll-like receptor is required for intestinal homeostasis / Cell 118 : 229 ~ 241
[학술지(정기간행물)] - Uronis JM / 2009 / Modulation of the intestinal microbiota alters colitis associated colorectal cancer susceptibility / PLoS One 4 : e6026 ~
[학술지(정기간행물)] - Honstettre A / 2004 / Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through tolllike receptor 4 / J Immunol 172 : 3695 ~ 3703
[학술지(정기간행물)] - Rakoff-Nahoum S / 2006 / Role of tolllike receptor in spontaneous commensal-dependent colitis / Immunity 25 : 319 ~ 329
[학술지(정기간행물)] - Rakoff-Nahoum S / 2004 / Recognition of commensal microflora by toll-like receptor is required for intestinal homeostasis / Cell 118 : 229 ~ 241
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UCI(KEPA) : I410-ECN-0101-2017-475-001400606