지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Asiasari radix (A. radix) is a traditional herb medicine that has been used as an analgesic, antitussive, or anti-allergic remedy. This study was performed to evaluate the effects of low concentration of the Asiasarum heterotropoides extract on the morphology and proliferation of the human mesenchymal stem cells derived from periodontal tissue.
Methods: Stem cells derived from gingiva were grown in the presence of A. radix at final concentrations that ranged from 0.001 to 0.01 μg/mL. The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed by using Cell Counting Kit-8 (CCK-8) on days 1 and 3.
Results: The control group showed fibroblast morphology. The shapes of the cells in 0.001 and 0.01 μg/mL of A. radix were similar to that of the untreated control group. The cultures growing in the presence of A. radix at day 1 showed an increase in the CCK-8 value. The relative values of CCK-8 assays of 0.001 and 0.01 μg/mL of A. radix are 130.6 % ± 1.8 % and 129.3 % ± 1.5 %, respectively, when the CCK-8 result of the untreated control group at day 1 is considered 100% (P = 0.051).
Conclusions: Within the limits of this study, low concentrations of A. radix seemed to increase the proliferation of the stem cells that were derived from the gingiva and did not have adverse effects on the morphology of the cells.
Methods: Stem cells derived from gingiva were grown in the presence of A. radix at final concentrations that ranged from 0.001 to 0.01 μg/mL. The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed by using Cell Counting Kit-8 (CCK-8) on days 1 and 3.
Results: The control group showed fibroblast morphology. The shapes of the cells in 0.001 and 0.01 μg/mL of A. radix were similar to that of the untreated control group. The cultures growing in the presence of A. radix at day 1 showed an increase in the CCK-8 value. The relative values of CCK-8 assays of 0.001 and 0.01 μg/mL of A. radix are 130.6 % ± 1.8 % and 129.3 % ± 1.5 %, respectively, when the CCK-8 result of the untreated control group at day 1 is considered 100% (P = 0.051).
Conclusions: Within the limits of this study, low concentrations of A. radix seemed to increase the proliferation of the stem cells that were derived from the gingiva and did not have adverse effects on the morphology of the cells.
목차
Introduction
Methodology
Results
Discussion
References
참고문헌 (32)
참고문헌 신청
[단행본] - Zhou RH / 1993 / Resource science of Chinese medicinal materials / China Medical & Pharmaceutical Sciences Press : 202 ~ 211
[학술지(정기간행물)] - Jang JY / 2010 / Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10cells / Int J Mol Med 25 : 287 ~ 292
[학술지(정기간행물)] - Jeong SH / 2014 / Effects of Asiasari radix on the morphology and viability of mesenchymal stem cells derived from the gingiva / Mol Med Rep 10 (6) : 3315 ~ 3319
[학술지(정기간행물)] - Kim HM / 1999 / Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo / Immunopharmacol Immunotoxicol 21 : 469 ~ 481
[학술지(정기간행물)] - Rho SS / 2005 / The hair growth promoting effect of Asiasari radix extract and its molecular regulation / J Dermatol Sci 38 : 89 ~ 97
[학술지(정기간행물)] - Jang JY / 2010 / Partially purified Asiasari radix inhibits melanogenesis through extracellular signal-regulated kinase signaling in B16F10cells / Int J Mol Med 25 : 287 ~ 292
[학술지(정기간행물)] - Jeong SH / 2014 / Effects of Asiasari radix on the morphology and viability of mesenchymal stem cells derived from the gingiva / Mol Med Rep 10 (6) : 3315 ~ 3319
[학술지(정기간행물)] - Kim HM / 1999 / Asiasari radix inhibits immunoglobulin E production on experimental models in vitro and in vivo / Immunopharmacol Immunotoxicol 21 : 469 ~ 481
[학술지(정기간행물)] - Rho SS / 2005 / The hair growth promoting effect of Asiasari radix extract and its molecular regulation / J Dermatol Sci 38 : 89 ~ 97
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UCI(KEPA) : I410-ECN-0101-2017-519-001005846