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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제2호
- 발행연도
- 2017.1
- 수록면
- 163 - 169 (7page)
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초록· 키워드
오류제보하기
Objective: The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate biomarkers in MDD have been reported, which might be a consequence of the heterogeneity of MDD patients. Therefore, we aim to investigate how the severity of depression and various symptom domains are related to the levels of dehydroepiandrosterone sulfate (DHEA-s) in MDD patients.
Methods: We recruited 117 subjects from a general practice. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). Depressive symptoms were divided into three subdomains according to BDI items; somatic symptoms, guilt and failure, and mood and inhibition.
Results: In subjects with very-mild-to-moderate depression, the DHEA-s level increased as BDI score did. However, the DHEA-s levels in the subjects with severe depression were significantly lower than in subjects with moderate depression (p=0.003). DHEA-s level was correlated with the BDI subscore for guilt and failure in very-mild-to-moderate depression (r=0.365, p=0.006).
Conclusion: The DHEA-s level appears to be indicative of MDD severity with respect to depressive symptoms, especially regarding guilt and failure. Our findings suggest that the upregulation of DHEA-s may be a part of a compensatory process in very-mild-to-moderate depression, and the failure of this compensation mechanism may underlie the development of severe depression.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Andrade L / 2003 / The epidemiology of major depressive episodes : results from the International Consortium of Psychiatric Epidemiology(ICPE)surveys / Int J Methods Psychiat
Capuron L / 2004 / Cytokines and psychopathology : lessons from interferon-alpha / Biol Psychiatry 56 : 819 ~ 824
Charney DS / 1998 / Monoamine dysfunction and the pathophysiology and treatment of depression / J Clin Psychiatry 59 (Suppl 14) : 11 ~ 14
Chen L / 2000 / Understanding the heterogeneity of depression through the triad of symptoms, course and risk factors: a longitudinal, population-based study / J Affect Disor
Duivis HE / 2013 / Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation : findings from the Netherlands Study of Depression
Capuron L / 2004 / Cytokines and psychopathology : lessons from interferon-alpha / Biol Psychiatry 56 : 819 ~ 824
Charney DS / 1998 / Monoamine dysfunction and the pathophysiology and treatment of depression / J Clin Psychiatry 59 (Suppl 14) : 11 ~ 14
Chen L / 2000 / Understanding the heterogeneity of depression through the triad of symptoms, course and risk factors: a longitudinal, population-based study / J Affect Disor
Duivis HE / 2013 / Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation : findings from the Netherlands Study of Depression
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