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논문 기본 정보

자료유형
학술저널
저자정보
양민영 (전북대학교) 윤정수 (전북대학교) 박대령 (전북대학교)
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제24권 제6호 (자연과학 편)
발행연도
2015.12
수록면
1,047 - 1,058 (12page)

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This study was to investigate the effects of Atypical MAPK signaling pathway expression on HSP27 expression which was small heat shock protein (HSP) related on damage and recovery of skeletal muscle. Generally, acute or high intensive exercise can elicit skeletal muscle injuries, cellular inflammatory response. Mitogen activated protein kinase (MAPK) highly involves exercise induced cell damage and recovery which have regulatory function on small HSP expression. MAPK is stimulated by stress and reative oxygen species induced by exercise. As a expect, MAPK may stimulates HSP27 which has protectional function of skeletal muscle cytoskeleton and is involved in protein synthesis and recovery. However exact regulatory mechanism between MAPK and HSP 27 not elucidated. To investigate the relation and regulatory function between Atypical MAPK and HSP27 during exercise and recovery, we did acute exercise and examined protein expression in gastrocnemius of ICR mouses by western blotting. Muscle harvest was various which divided by 5 time point (exercise: 15mins, 60mins / recovery: 6hours, 12hours), and control groups. As a result, the proteins expression of MAPK sub factors, PAK2, ERK3, and MK5, showed similar tendency to aspects of HSP27 revelation during exercise and recovery period. However, PAK1 was seen an inverse tendency different from other MAPK sub factors during exercise and recovery period. PAK1, in general, was seen a similar tendency to HEK293, PC12 cell, and had a same tendency to the result of preceding studies on the importance of signaling pathway to maintain the cell homeostasis. Thus, Atypical MAPK signaling pathway was important to prevent from skeletal muscle injuries caused by exercise stress.

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Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
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UCI(KEPA) : I410-ECN-0101-2016-692-002290483