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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 1,249 - 1,259 (11page)
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이 논문의 연구 히스토리 (3)
2015
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The Aim of this study was to investigate the effect of acute endurance exercise on expression of MK5 related protein kinases in SD rat skeletal muscle. The male SD rat(N=20) was ran the treadmill running with various running intensity(VO₂max 40~80%) and soleus and extensor digitorum longus muscle was harvested for analysis. Western blooting was performed for the expression of HSP27 and p38 MAPK phosphorylation, ERK3 and MK5. The skeletal muscle’s cAMP changes was analysed by ELISA. The cAMP level was not significantly increased by exercise intensity increase however the MK5 and HSP27 expression level was significantly increased. Also p38 MAPK level was significantly increased in solues but EDL was not. importantly, novel MK5 activator, ERK3 was significantly increased coinside with the MK5 and HSP27 expression. As results, We derived the conclusion that ERK3 is a novel MK5 activator in skeletal muscle when exercise. However, a downside of these experiments in that the reason and process for direct evidence for ERK3 activation is still unknown.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
참고문헌
참고문헌 (24)
참고문헌 신청
1. [학위논문] - 박대령 / 2010 / 일회성 운동 및 운동 후 회복기 흰쥐 골격근의 small HSP 관련 신호단백질의 발현 / 박사 / 전북대학교 대학원
2. [학술지(정기간행물)] - Aberg E / 2009 / Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif / J Biol Chem 284 (29) : 19392 ~ 19401
3. [학술지(정기간행물)] - Bao W / 2007 / Effects of p38 MAPK Inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production / J Cardiovasc Pharmacol 49 (6) : 362 ~ 368
4. [학술지(정기간행물)] - Bedford, T. G / 1979 / maximum oxygen consumption of rats and its changes with various experimental procedures / J Appl Physiol 47 (6) : 1278 ~ 1283
5. [학술지(정기간행물)] - Calderwood, S. K. / 2007 / Extracellular heat shock proteins in cell signaling and immunity / Ann N Y Acd Sci 1113 : 28 ~ 39
2. [학술지(정기간행물)] - Aberg E / 2009 / Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif / J Biol Chem 284 (29) : 19392 ~ 19401
3. [학술지(정기간행물)] - Bao W / 2007 / Effects of p38 MAPK Inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production / J Cardiovasc Pharmacol 49 (6) : 362 ~ 368
4. [학술지(정기간행물)] - Bedford, T. G / 1979 / maximum oxygen consumption of rats and its changes with various experimental procedures / J Appl Physiol 47 (6) : 1278 ~ 1283
5. [학술지(정기간행물)] - Calderwood, S. K. / 2007 / Extracellular heat shock proteins in cell signaling and immunity / Ann N Y Acd Sci 1113 : 28 ~ 39
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UCI(KEPA) : I410-ECN-0101-2014-690-003230590