지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 227 - 232 (6page)
이용수
초록· 키워드
오류제보하기
Epstein-Barr virus (EBV) has a pathogenic role in several lymphomas including diffuse large B-cell lymphoma (DLBCL). In this study, we detected EBV from formalin-fixed paraffin embedded (FFPE) tissues of DLBCL patients by RT-PCR and compared the sensitivity of the RT-PCR method to in situ hybridization (ISH) method. The RNA was extracted from 91 FFPE samples with DLBCL and amplified with primers targeting EBV-encoded small RNA (EBER) by RT-PCR. When using the RT-PCR method, 13 of 91 patients (14.3%) were positive and among these 13 cases, 7 cases (7.7%) were from > 50-year-old patients that is classified as EBV positive DLBCL of the elderly. In previous results using ISH method, 3 of 91 patients (3.3%) were positive and 2 case (2.4%) were older than 50-year-old. These results indicate that RT-PCR method used in this study shows a higher sensitivity than ISH method. The ratio of male versus female among the EBV positive samples was 1.2:1 with the ratio of male higher. If RT-PCR method having high sensitivity is used simultaneously as well as the ISH method providing the information of the EBV positive cellular location, it is expected that EBV will be more accurately detected.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSIONS
REFERENCES
참고문헌 (31)
참고문헌 신청
[학술지(정기간행물)] - Anagnostopoulos I / 1996 / Epstein-Barr virus in tumours / Histopathology 29 : 297 ~ 315
[학술지(정기간행물)] - Beltran BE / 2011 / EBV-positive diffuse large B-cell lymphoma of the elderly:a case series from Peru / Am J Hematol 86 : 663 ~ 667
[학술지(정기간행물)] - Bonin S / 2003 / PCR analysis in archival postmortem tissues / Mol Pathol 56 : 184 ~ 186
[학술지(정기간행물)] - Chang KL / 1992 / Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues / Diagn Mol Pathol 1 : 246 ~ 255
[보고서] - Epstein A / 1994 / Thirty years of Epstein-Barr virus : 3 ~ 4
[학술지(정기간행물)] - Beltran BE / 2011 / EBV-positive diffuse large B-cell lymphoma of the elderly:a case series from Peru / Am J Hematol 86 : 663 ~ 667
[학술지(정기간행물)] - Bonin S / 2003 / PCR analysis in archival postmortem tissues / Mol Pathol 56 : 184 ~ 186
[학술지(정기간행물)] - Chang KL / 1992 / Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues / Diagn Mol Pathol 1 : 246 ~ 255
[보고서] - Epstein A / 1994 / Thirty years of Epstein-Barr virus : 3 ~ 4
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UCI(KEPA) : I410-ECN-0101-2016-510-002322021