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Clinical Significance of Epstein-Barr Virus and Helicobacter pylori Infection in Gastric Carcinoma
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논문 기본 정보

Type
Academic journal
Author
Noh Jin Hee (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Shin Jun Young (Department of Pathology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Lee Jeong Hoon (Department of Gastroenterology Asan Medical Center University of Ulsan College of Medicine Seoul Korea)
Journal
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제17권 제1호 KCI Accredited Journals SCOPUS
Published
2023.1
Pages
69 - 77 (9page)
DOI
10.5009/gnl210593

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Clinical Significance of Epstein-Barr Virus and Helicobacter pylori Infection in Gastric Carcinoma
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Background/Aims: Epstein-Barr virus (EBV) and Helicobacter pylori (HP) coinfection may synergistically induce severe inflammatory responses in the stomach tissue, increasing the risk of developing gastric cancer. We aimed to analyze the effect of EBV and HP coinfection on the clinicopathologic features and prognosis of gastric cancer, as well as to evaluate the role of EBV infection in non-gastric carcinoma with lymphoid stroma (non-GCLS). Methods: Overall, 956 patients who underwent surgery for gastric cancer between September 2014 and August 2015 were eligible and divided into groups, according to GCLS morphology, EBV infection, and HP infection. Clinicopathologic characteristics and oncologic outcomes were analyzed retrospectively. Results: EBV and HP coinfection was significantly associated with male sex, proximal location, GCLS morphology, and equivocal p53 expression (p<0.001). Multivariate analysis revealed that EBV infection alone (hazard ratio [HR], 0.362; 95% CI, 0.131 to 0.996; p=0.049) and lower third location (HR, 0.624; 95% CI, 0.413 to 0.943; p=0.025) were inversely correlated with overall survival. During median follow-up period of 72 months, overall survival rate was not significantly different between the EBV and HP coinfection group and others (97.6% vs 86.8%, log-rank p=0.144). In non-GCLS patients (n=920), overall survival rate was not significantly different between the EBV infection group and others (96.9% vs 86.4%, log-rank p=0.126). Conclusions: EBV and HP coinfection is not an independent prognostic factor for gastric cancer. EBV infection status, regardless of HP infection, affects the clinicopathologic features of all types of gastric cancer. However, it does not lead to a significant difference in overall survival of non-GCLS patients.
#Coinfection #Gastric cancer #Gastric carcinoma with lymphoid stroma #Prognosis

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