지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 218 - 226 (9page)
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초록· 키워드
오류제보하기
The present study investigated the mechanisms of licochalcone B (LicB)-mediated inhibition of the inflammatory response in murine macrophages. RAW264.7 murine macrophages were cultured in the absence or presence of lipopolysacharide (LPS) with LicB. LicB suppressed the generation of nitric oxide and the pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumor necrosis factor-α. LicB also inhibited the expression of mRNA for inducible nitric oxide synthase and pro-inflammatory cytokines induced by LPS. Moreover, LicB inhibited nuclear factor-κB (NF-κB) and activator protein-1 translocation into the nucleus in a dose-dependent manner. Thus, LicB mainly exerts its antiinflammatory effects by inhibiting the LPS-induced NF-κB and activator protein-1 signaling pathways in macrophages, which subsequently diminishes the expression and release of various inflammatory mediators. LicB shows promise as a therapeutic agent in inflammatory diseases.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
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[학술지(정기간행물)] - Arango DG / 2014 / Macrophage cytokines: involvement in immunity and infectious diseases / Front Immunol 8 : 319 ~
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[학술지(정기간행물)] - Baker RG / 2011 / NF-κB, inflammation, and metabolic disease / Cell Metab 13 : 11 ~ 22
[학술지(정기간행물)] - Balunas MJ / 2005 / Drug discovery from medicinal plants / Life Sci 78 : 431 ~ 441
[학술지(정기간행물)] - Arango DG / 2014 / Macrophage cytokines: involvement in immunity and infectious diseases / Front Immunol 8 : 319 ~
[학술지(정기간행물)] - Asl MN / 2008 / Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds / Phytother Res 22 : 709 ~ 724
[학술지(정기간행물)] - Baker RG / 2011 / NF-κB, inflammation, and metabolic disease / Cell Metab 13 : 11 ~ 22
[학술지(정기간행물)] - Balunas MJ / 2005 / Drug discovery from medicinal plants / Life Sci 78 : 431 ~ 441
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UCI(KEPA) : I410-ECN-0101-2016-510-002322016