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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives: The purpose of this study was to evaluate the effects of Polyporus Herbal-acupuncture(PO-HA) at KI10(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats.
Methods: Rats were allocated into normal, control, and 2 experimental groups. The rats in the control group were intra-peritoneally injected with LPS for nephritis induction. The rats in the groups of experiment 1 and experiment 2 were treated with Saline injection, and PO-HA, respectively at KI10 three times for a week and then intra-peritoneally injected with LPS. To evaluate the effects of PO-HA at KI10, WBC count in blood, creatine, tumor necrosis factor-alpha (TNF-α), cytokine-induced neutrophil chemoattractant 1(CINC-1) in serum, urinary volume, creatinine, total protein in urine, myeloperoxidase(MPO) in kidney were measured.
Results: PO-HA at KI10 significantly suppressed the increase of WBC in blood, TNF-α, CINC-1 in serum, MPO in kidney of LPS-stimulated rats. PO-HA at KI10 significantly suppressed the increase creatinine, total protein in urine of LPS-stimulated rats.
Conclusions: According to these results, it is postulated that PO-HA at KI10 has an anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats. Therefore, it is suggested that PO-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
Methods: Rats were allocated into normal, control, and 2 experimental groups. The rats in the control group were intra-peritoneally injected with LPS for nephritis induction. The rats in the groups of experiment 1 and experiment 2 were treated with Saline injection, and PO-HA, respectively at KI10 three times for a week and then intra-peritoneally injected with LPS. To evaluate the effects of PO-HA at KI10, WBC count in blood, creatine, tumor necrosis factor-alpha (TNF-α), cytokine-induced neutrophil chemoattractant 1(CINC-1) in serum, urinary volume, creatinine, total protein in urine, myeloperoxidase(MPO) in kidney were measured.
Results: PO-HA at KI10 significantly suppressed the increase of WBC in blood, TNF-α, CINC-1 in serum, MPO in kidney of LPS-stimulated rats. PO-HA at KI10 significantly suppressed the increase creatinine, total protein in urine of LPS-stimulated rats.
Conclusions: According to these results, it is postulated that PO-HA at KI10 has an anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats. Therefore, it is suggested that PO-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
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참고문헌
참고문헌 (33)
참고문헌 신청
[단행본] - Du HK / 1993 / Oriental Kidney System Internal Medicine / Institute of the oriental science : 226 ~
[단행본] - Du HK / 1993 / Oriental Kidney System Internal Medicine / Institute of the oriental science : 225 ~
[단행본] - Committee of Korean Textbook Publisher / 1999 / Herbology / Yeong Lim Sa : 304 ~ 305
[단행본] - Kim CM / 2004 / The encyclopedia of Oriental herbal medicine / Jung Dam : 3700 ~
[학술지(정기간행물)] - Sun Y / 2008 / New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus / Bioorganic &Medicinal Chemistry Letters 18 : 3417 ~ 3420
[단행본] - Du HK / 1993 / Oriental Kidney System Internal Medicine / Institute of the oriental science : 225 ~
[단행본] - Committee of Korean Textbook Publisher / 1999 / Herbology / Yeong Lim Sa : 304 ~ 305
[단행본] - Kim CM / 2004 / The encyclopedia of Oriental herbal medicine / Jung Dam : 3700 ~
[학술지(정기간행물)] - Sun Y / 2008 / New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus / Bioorganic &Medicinal Chemistry Letters 18 : 3417 ~ 3420
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UCI(KEPA) : I410-ECN-0101-2016-519-002007200