Case report of renal cell carcinoma in automobile manufacturing factory worker due to trichloroethylene exposure in Korea

June-Hee Lee; Inah Kim; Hongdeok Seok; Inhyo Park; Jungho Hwang; Jae-Oh Park; Jong-Uk Won; Jaehoon Roh

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자료유형: 학술저널

저자정보: June-Hee Lee (Yonsei University) Inah Kim (Hanyang University College of Medicine) Hongdeok Seok (Yonsei University) Inhyo Park (Yonsei University) Jungho Hwang (Yonsei University College of Medicine) Jae-Oh Park (Korea Occupational Safety and Health Agency) Jong-Uk Won (Yonsei University) Jaehoon Roh (Yonsei University)

저널정보: 대한직업환경의학회 대한직업환경의학회지 대한직업환경의학회지 제27권 제8호

발행연도: 2015.8

수록면: 1 - 5 (5page)

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Background: The aim of this paper was report first case of renal cell carcinoma developed in a worker who worked in an automobile manufacture line which handles trichloroethylene in Korea.
Case presentation: To clarify the relationship between the onset of renal cell carcinoma in 52-years old male worker and the exposure to trichloroethylene, document studies and work environment measurement were done. Past work environment exposure data were reviewed and medical history and surgery records of the worker were also reviewed. The patient had no personal risk factor related to renal cell carcinoma except for his smoking habit of quarter a pack per day for twenty years, and since trichloroethylene was not part of measurement criteria, past work environment risk assessment data could not verify the exposure. The exposure level is deduced by analyzing material exposure level of work environments which has similar processes in data from revised research of chemical exposure standard and work environment validity assessment. Evaluation Committee of Epidemiologic Survey decided that there are relevant relationship between the exposure and the disease, though we do not have exact data during that period, most experts agree that in every factories they used trichloroethylene without any direction.
Conclusions: From the relevant medical history and the results of the usage of trichloroethylene in the relevant industries, and initial discovery of renal cell carcinoma at health inspection sonogram in 2001, it can be concluded that suggests significant causal relationship between the exposure to trichloroethylene and renal cell carcinoma onset, thus reporting it to be the first domestic case declared to be occupational disease.

#Trichloroethylene #Occupational disease #Carcinoma #Renal cell #Automobiles #Korea

참고문헌 (18)

참고문헌 신청

Kimbrough RD / 1985 / Trichloroethylene: an update / J Toxicol Environ Health A 15(3-4):369~383

Dekant W / 1984 / Novel metabolites of trichloroethylene through dechlorination reactios in rats, mice and humans / Biochem Pharmacol 33(13):2021~2027

Guha NLD / 2012 / International agency for research on cancer monograph working group : Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites / Lancet Oncol 13:1192~1193

McCredie M / 1988 / Risk factors for cancer of the renal parenchyma / Int J Cancer 42(1):13~16

McGregor DB / 1995 / Dry cleaning, some solvents used in dry cleaning and other industrial chemicals / Scand J Work Environ Health 21:310~312

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