지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 150 - 160 (11page)
이용수
초록· 키워드
오류제보하기
We previously reported that 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) accelerates hematopoiesis and has an improving effect on animal disease models such as sepsis and asthma. The effects of PLAG supplementation on immune modulation were assessed in healthy men and women. The objective was to evaluate the effects of PLAG supplementation on immune regulatory functions such as activities of immune cells and cytokine production. A randomized double blind placebo-controlled trial was conducted. Seventy-five participants were assigned to one of two groups; all participants had an appropriate number of white blood cells on the testing day. The PLAG group (n=27) received oral PLAG supplements and the control group (n=22) received oral soybean oil supplements. IL-4 and IL-6 production by peripheral blood mononuclear cells (PBMC) were lower (p＜0.001 and p＜0.001, respectively) with PLAG than with soybean oil. However, the production of IL-2 and IFN-γ by PBMC was unaltered with PLAG supplementation. The B cell proliferation decreased significantly in the PLAG group compared to the soybean oil control (p＜0.05). The intake of PLAG in healthy adults for 4 weeks was deemed safe. These data suggest that PLAG has an immunomodulatory function that inhibits the excessive immune activity of immunological disorders such as atopic and autoimmune diseases. PLAG could improve the condition of these diseases safely as a health food supplement.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (36)
참고문헌 신청
[학술지(정기간행물)] - Wu, F. / 2013 / Deer antler base as a traditional Chinese medicine: a review of its traditional uses, chemistry pharmacology / J. Ethnopharmacol 145 : 403 ~ 415
[학술지(정기간행물)] - Gilbey, A. / 2012 / Health benefits of deer elk velvet antler supplements: a systematic review of randomised controlled studies / N. Z. Med. J 125 : 80 ~ 86
[학술지(정기간행물)] - Allen, M. / 2008 / A randomized clinical trial of elk velvet antler in rheumatoid arthritis / Biol. Res. Nurs 9 : 254 ~ 261
[학술지(정기간행물)] - Yang, H. O. / 2004 / Stimulatory effects of monoacetyldiglycerides on hematopoiesis / Biol. Pharm. Bull 27 : 1121 ~ 1125
[학술지(정기간행물)] - Kleiman, R. / 1966 / Optically active aceto-triglycerides of oil fromEuonymus verrucosus seed / Lipids 1 : 286 ~ 287
[학술지(정기간행물)] - Gilbey, A. / 2012 / Health benefits of deer elk velvet antler supplements: a systematic review of randomised controlled studies / N. Z. Med. J 125 : 80 ~ 86
[학술지(정기간행물)] - Allen, M. / 2008 / A randomized clinical trial of elk velvet antler in rheumatoid arthritis / Biol. Res. Nurs 9 : 254 ~ 261
[학술지(정기간행물)] - Yang, H. O. / 2004 / Stimulatory effects of monoacetyldiglycerides on hematopoiesis / Biol. Pharm. Bull 27 : 1121 ~ 1125
[학술지(정기간행물)] - Kleiman, R. / 1966 / Optically active aceto-triglycerides of oil fromEuonymus verrucosus seed / Lipids 1 : 286 ~ 287
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UCI(KEPA) : I410-ECN-0101-2016-511-001754688