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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 13 - 20 (8page)
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Coptis chinensis rhizome has been used as a medicinal herb in traditional Oriental medicine. We investigated the effects of Coptis chinensis extract on inflammatory mediators and delayed type hypersensitivity in mice. Methods: The inhibitory effect of ethanolic extract of Coptis chinensis (CCE) on cell proliferation was evaluated using MTS assay. The lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the Con A-activated mouse splenocytes were cultured with various concentrations of CCE. Total nitric oxide (NO) production was determined by Griess reaction. The amounts of secreted prostaglandine E2 (PGE<sub>2</sub>), interleukin (IL)-2 and IFN-γ were measured by ELISA. To investigate the in vivo anti-inflammatory effect of CCE, oxazolone-induced delayed type hypersensitivity (DTH) model was used. Results: The CCE at 100μg/ml significantly blocked the LPS-induced production of pro-inflammatory mediators (NO and PGE) in RAW264.7 macrophages. Also, it significantly inhibited cell proliferation and cytokine (IL-2 and IFN-γ) production in splenocytes. Furthermore, when splenocytes from CCE fed mice (200 mg/kg for 2 weeks) were activated with Con A, cell proliferation and cytokine production were significantly inhibited. In addition, CCE decreased in vivo inflammation in oxazolone-induced DTH model mice. Conclusion: We suggest that Coptis chinensis can be used as an anti-inflammatory drug by exerting an inhibitory effect in inflammatory mediator- and cell-mediated inflammation.
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참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Wu MJ / 2004 / Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-Kb / J Biomed Sci 11 : 186 ~ 199
2. [학술지(정기간행물)] - Dinarello CA / 1998 / Interleukin-1, interleukin-1 receptors and interlekin-1 receptor antagonist / Int Rev Immunol 16 : 457 ~ 499
3. [학술지(정기간행물)] - Nathan C / 1995 / Natural resistance and nitric oxide / Cell 82 : 873 ~ 876
4. [학술지(정기간행물)] - Fenton MJ / 1998 / LPS-binding proteins and receptors / J Leukoc Biol 64 : 25 ~ 32
5. [학술지(정기간행물)] - Glauser MP / 1996 / The inflammatory cytokines. New developments in the pathophysiology and treatment of septic shock / Drugs 52 : 9 ~ 17
2. [학술지(정기간행물)] - Dinarello CA / 1998 / Interleukin-1, interleukin-1 receptors and interlekin-1 receptor antagonist / Int Rev Immunol 16 : 457 ~ 499
3. [학술지(정기간행물)] - Nathan C / 1995 / Natural resistance and nitric oxide / Cell 82 : 873 ~ 876
4. [학술지(정기간행물)] - Fenton MJ / 1998 / LPS-binding proteins and receptors / J Leukoc Biol 64 : 25 ~ 32
5. [학술지(정기간행물)] - Glauser MP / 1996 / The inflammatory cytokines. New developments in the pathophysiology and treatment of septic shock / Drugs 52 : 9 ~ 17
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