지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 283 - 288 (6page)
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초록· 키워드
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The pro-inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin (IL)-1β are crucial mediators involved in chronic inflammatory diseases. Inflammatory signal pathways regulate inflammatory cytokine expression-mediated by p38 mitogen activated protein kinase (p38MAPK). Therefore, considerable attention has been given to p38MAPK as a target molecule for the development of a novel anti-inflammatory therapeutics. BIRB 796, one of p38MAPK inhibitor, is a candidate of therapeutic drug for chronic inflammatory diseases. In this study, we investigated the effect of BIRB 796 on inflammatory cytokine productions by lipopolysaccharide (LPS) in different immune cell types. BIRB 796 reduced LPS-mediated IL-8 production in THP-1 cells but not in Raw 264.7 cells. Further analysis of signal molecules by western blot revealed that BIRB 796 sufficiently suppressed LPS-mediated phosphorylation of p38MAPK in both cell types whereas it failed to block inhibitor of kappa B (I-κB) degradation in Raw 264.7 cells. Taken together, these results suggest that the anti-inflammatory function of BIRB 796 depends on cell types.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Feldmann, M. / 1996 / Role of cytokines in rheumatoid arthritis / Annu. Rev. Immunol 14 : 397 ~ 440
2. [학술지(정기간행물)] - Jarvis, B. / 1999 / Etanercept: a review of its use in rheumatoid arthritis / Drugs 57 : 945 ~ 966
3. [학술지(정기간행물)] - Weinblatt, M. E. / 1999 / A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate / N. Engl. J. Med 340 : 253 ~ 259
4. [학술지(정기간행물)] - Dinarello, C. A. / 2004 / Interleukin-18 and the treatment of rheumatoid arthritis / Rheum. Dis. Clin. North. Am 30 : 417 ~ 434
5. [학술지(정기간행물)] - Schafer, P. H. / 1999 / T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes / J. Immunol 162 : 659 ~ 668
2. [학술지(정기간행물)] - Jarvis, B. / 1999 / Etanercept: a review of its use in rheumatoid arthritis / Drugs 57 : 945 ~ 966
3. [학술지(정기간행물)] - Weinblatt, M. E. / 1999 / A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate / N. Engl. J. Med 340 : 253 ~ 259
4. [학술지(정기간행물)] - Dinarello, C. A. / 2004 / Interleukin-18 and the treatment of rheumatoid arthritis / Rheum. Dis. Clin. North. Am 30 : 417 ~ 434
5. [학술지(정기간행물)] - Schafer, P. H. / 1999 / T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes / J. Immunol 162 : 659 ~ 668
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UCI(KEPA) : I410-ECN-0101-2016-511-001746028