CD44 expression in patients with combined hepatocellular cholangiocarcinoma

Ryounggo Kim; Sang Bum Kim; Eung-Ho Cho; Sun Hoo Park; Sung Bae Park; Seong Kweon Hong; Gibong Chae

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저자정보: Ryounggo Kim (Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) Sang Bum Kim (Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) Eung-Ho Cho (Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) Sun Hoo Park (Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences) Sung Bae Park (Kangwon National University Hospital) Seong Kweon Hong (Kangwon National University Hospital) Gibong Chae (Kangwon National University Hospital)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.89 No.1

발행연도: 2015.6

수록면: 9 - 16 (8page)

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2015

CD44 expression in patients with combined hepatocellular cholangiocarcinoma

Ryounggo Kim , Sang Bum Kim , Eung-Ho Cho 외 6명 Annals of Surgical Treatment and Research 2015.06 학술저널

CD44 expression is associated with poor prognosis in patients with combined hepatocellular cholangiocarcinoma : 혼합형 간세포-담도암 환자에서 CD44의 발현양상과 예후와의 연관성

Ryounggo Kim 의학과 2015.01 학위논문

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Purpose: Combined hepatocellular cholangiocarcinoma (ChC) is a rare type of primary liver cancer, which is thought to have a poorer prognosis than hepatocellular carcinoma (HCC). Cancer stem cells are associated with tumorigenesis, tumor progression, recurrence, metastasis, and poor prognosis in several malignancies including HCC. The aim of this study was to investigate the expression pattern of cancer stem cell markers in ChC and HCC, and to evaluate whether this pattern correlated to patient prognosis.
Methods: Thirteen patients who underwent curative hepatic resection for ChC and 13 patients who underwent curative hepatic resection for HCC (matched control cases) were included. Immunohistochemical staining for cancer stem cell markers (cytokeratin [CK]7, CK19, C-kit, cluster of differentiation [CD] 44, CD133, and epithelial cell adhesion molecule) was performed and clinical outcomes were analyzed retrospectively.
Results: There was no significant difference in cancer stem cell marker expression between ChC and HCC. In ChC, the group that expressed CD44 showed earlier recurrence than the group that did not express CD44 (P = 0.040).
Conclusion: The expression of cancer stem cell markers in ChC did not show a different pattern compared to that found in HCC. The expression of cancer stem cell marker CD44 was associated with poor prognosis in patients with ChC.

#Hepatocellular carcinoma #Cholangiocarcinoma #Neoplastic stem cells #Cluster of Differentiation 44 (CD44)

참고문헌 (25)

참고문헌 신청

[학술지(정기간행물)] - Taguchi J. / 1996 / A clinicopathological study on combined hepatocellular and cholangiocarcinoma / J Gastroenterol Hepatol 11 : 758 ~ 764

[학술지(정기간행물)] - Yano Y. / 2003 / Combined hepatocellular and cholangiocarcinoma : a clinicopathologic study of 26 resected cases / Jpn J Clin Oncol 33 : 283 ~ 287

[학술지(정기간행물)] - Koh KC. / 2005 / Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma / Am J Surg 189 : 120 ~ 125

[학술지(정기간행물)] - Portolani N. / 2008 / Intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma : a Western experience / Ann Surg Oncol 15 : 1880 ~ 1890

[학술지(정기간행물)] - Yu XH. / 2011 / Clinicopathological analysis of 14 patients with combined hepatocellular carcinoma and cholangiocarcinoma / Hepatobiliary Pancreat Dis Int 10 : 620 ~ 625

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