지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 61 - 65 (5page)
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Objectives: In this study, we investigated the oral toxicity of Gami-Jakyak Gamcho buja Decoction (Mecasin) to develop safe treatments.
Methods: All experiments were conducted at the Medvill, an institution authorized to perform non-clinical studies, under the Good Laboratory Practice (GLP) regulations. In order to investigate the oral toxicity of Mecasin, we administered Mecasin orally to rats. Sprague-Dawley rats were divided into four groups of five male and five female animals per group: group 1 being the control group and groups 2, 3, and 4 being the experimental groups. Doses of Mecasin, 500 mg/kg, 1,000 mg/kg and 2,000 mg/kg, were administered to the experimental groups, and a dose of normal saline solution, 10 mL/kg, was administered to the control group. We examined the survival rate, weight, clinical signs, and gross findings. This study was conducted under the approval of the Institutional Animal Ethics Committee.
Results: No deaths or abnormalities occurred in any of the four groups. Although slight decreases in the weights of some female rats were noted on the third day, no significant changes in weights or gross findings between the control group and the experimental groups were observed. To check for abnormalities in organs, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs.
Conclusion: The results showed that administration of 500 − 2,000 mg/kg of Mecasin did not cause any changes in weight or in the results of necropsy examinations. It also did not result in any mortalities. The above findings suggest that treatment with Mecasin is relatively safe. Further studies on this subject are needed to yield more concrete evidence.
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참고문헌 (25)
참고문헌 신청
Elinav E. / 2003 / Licorice consumption causing severe hypokalemic paralysis / Mayo Clin Proc 78 (6) : 767 ~ 768
Fang YS. / 2009 / Effect of constituents from fructus aurantii immaturus and radix paeoniae alba on gastrointestinal movement / Planta Med 75 (1) : 24 ~ 31
Guo L. / 2007 / Orthogonal array design for optimizing extraction efficiency of active constituents from jakyak-gamcho decoction, the complex formula of herbal medicines, pae
Hu F. / 2012 / The cardioprotective effect of danshen and gegen decoction on rat hearts and cardiomyocytes with post-ischemia reperfusion injury / BMC Complement Altern Med
Huang KS. / 2011 / Paeoniae alba radix promotes peripheral nerve regeneration / Evid Based Complement Alternat Med 109809 : 1 ~ 8
Fang YS. / 2009 / Effect of constituents from fructus aurantii immaturus and radix paeoniae alba on gastrointestinal movement / Planta Med 75 (1) : 24 ~ 31
Guo L. / 2007 / Orthogonal array design for optimizing extraction efficiency of active constituents from jakyak-gamcho decoction, the complex formula of herbal medicines, pae
Hu F. / 2012 / The cardioprotective effect of danshen and gegen decoction on rat hearts and cardiomyocytes with post-ischemia reperfusion injury / BMC Complement Altern Med
Huang KS. / 2011 / Paeoniae alba radix promotes peripheral nerve regeneration / Evid Based Complement Alternat Med 109809 : 1 ~ 8
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