지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 464 - 471 (8page)
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Background/Aims: Epithelial-mesenchymal transition (EMT) is a developmental process, wherein the epithelial cells show reducedintercellular adhesions and acquire migratory fibroblastic properties. EMT is associated with downregulation in epithelial markerexpression, abnormal translocation of E-cadherin, and upregulation in mesenchymal marker expression. Here, we investigated theimmunohistochemical (IHC) expression of EMT markers in early gastric cancer (EGC) between cancer and noncancer tissues. Methods: Tissue samples were prospectively obtained from 19 patients with EGC that underwent endoscopic submucosal dissection(ESD). We compared the expression level of transforming growth factor (TGF)-β, vascular endothelial growth factor (VEGF),E-cadherin, α-smooth muscle actin (α-SMA), and vimentin between cancer and noncancer tissues using IHC. Among the 19 patients,15 patients had follow-up biopsy at 3 months after ESD for EGC. Results: Cancer tissues presented higher values of EMT mesenchymal markers (α-SMA/vimentin/TGF-β/VEGF) than thenoncancerous tissues (p<0.05) that were significantly low after ESD (p<0.05). No significant correlation was reported for tumor locationand initial Helicobacter pylori infection. Conclusions: The mesenchymal expression of EMT markers was higher in the cancerous tissues than in the noncancer tissues.
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참고문헌 (24)
참고문헌 신청
Hyun Jik Lee / 2018 / Characteristics of Synchronous and Metachronous Multiple Gastric Tumors after Endoscopic Submucosal Dissection of Early Gastric Neoplasm / Clinical Endoscopy 51(3):266~273
Thiery JP / 2009 / Epithelial-mesenchymal transitions in development and disease / Cell 139:871~890
Natalwala A / 2008 / Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract / World J Gastroenterol 14:3792~3797
López-Novoa JM / 2009 / Inflammation and EMT : an alliance towards organ fibrosis and cancer progression / EMBO Mol Med 1:303~314
Zhu Y / 2007 / Expression of TGF-β1, Snail, E-cadherin and N-cadherin in gastric cancer and its significance / Chinese Journal of Clinical Oncology 4:384~389
Thiery JP / 2009 / Epithelial-mesenchymal transitions in development and disease / Cell 139:871~890
Natalwala A / 2008 / Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract / World J Gastroenterol 14:3792~3797
López-Novoa JM / 2009 / Inflammation and EMT : an alliance towards organ fibrosis and cancer progression / EMBO Mol Med 1:303~314
Zhu Y / 2007 / Expression of TGF-β1, Snail, E-cadherin and N-cadherin in gastric cancer and its significance / Chinese Journal of Clinical Oncology 4:384~389
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Tumor-Associated Macrophages Derived TGF-β-Induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells through Smad2,3-4/Snail Signaling Pathway
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Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer
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만성 Helicobacter pylori 감염에 의한 위암발생에서 위줄기세포의 역할
Korean Journal of Helicobacter Upper Gastrointestinal Research
2015 .01
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Prognostic significance of programmed cell death-ligand 1 expression on immune cells and epithelialmesenchymal transition expression in patients with hepatocellular carcinoma
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Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway
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Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition
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Epithelial-mesenchymal Transition is Associated with Acquired Resistance to 5-Fluorocuracil in HT-29 Colon Cancer Cells
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2015 .06
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