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자료유형
학술저널
저자정보
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제17권 제2호
발행연도
1987.12
수록면
89 - 97 (9page)

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Hantaan virus, the etiologic agent of Korean hemorrhagic fever (KHF), was discovered from lungs of the Korean striped field mice (A podemus agrarius coreae) by Lee and Lee in 1976. Since that time, the natural reservoirs of Hantavirus, a new genus narne in which four serotypes of Hantaan and related virus, have been demonstrated to be wild rodents such as A podemus, Microtus, Chlethrionomys mice, and rats. This is the result of survey on the field status of infection of field mice with Hantaan virus among rodents collected in the different areas in where KHF patients had occurred in 1983. 1. The ratio of seropositive A podemus mice against Hantaan virus captured in locus A in Gyunnam-Myeon, Yeonchun-Kun, Kyunggi Province was about 49% and the ratio of antigen positive was about 38%. The ratios of seropositive and antigen positive Apodemus mice captured in locus B in Gyunnam-Myeon, were about 19% and 13%, respectively. 2. The ratio of seropositive and antigen positive Apodemus mice captured in Baekdal-Ri, Heongsung-Kun, Kangwon Province were about 16% and 8%, respectively. 3. Hantaan viral antigen was always detectable arnong lungs of seropositive A podemus mice to Hantaan virus. 4. The antibodies against Hantaan virus were demonstrated in serum from a Chlethrion omys mouse in Korea for the first time. 5. Eight strains of Hantaan virus were isolated from lungs of Apoodemus mice and in Vero E6 cells and the cell line was proved to be the most promising detector systern for isolation of the virus. It was demonstrated that the possibility of a role of Clhethrionomys mice as a reservoir of Hantaan virus in Korea and being able to isolate Hantaan virus without difficulty by using Vero E6 cell culture as a detector.

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