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논문 기본 정보

자료유형
학술저널
저자정보
Yang, Dong Kwon (Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Biosafety Research Institute and Korea Zoonosis Research Institute, Center for Poultry Diseases Co) Kang, Hyung-Sub (Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Biosafety Research Institute and Korea Zoonosis Research Institute, Center for Poultry Diseases Co)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제26권 제2호
발행연도
2018.1
수록면
130 - 138 (9page)

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Quercetin and resveratrol are known to have beneficial effects on the diabetes and diabetic complication, however, the effects of combined treatment of these compounds on diabetes are not fully revealed. Therefore, the present study was designed to investigate the combined antidiabetic action of quercetin (QE) and resveratrol (RS) in streptozotocin (STZ)-induced diabetic rats. To test the effects of co-treated with these compounds on diabetes, serum glucose, insulin, lipid profiles, oxidative stress biomarkers, and ions were determined. Additionally, the activities of hepatic glucose metabolic enzymes and histological analyses of pancreatic tissues were evaluated. 50 male Sprague-Dawley rats were divided into five groups; normal control, 50 mg/kg STZ-induced diabetic, and three (30 mg/kg QE, 10 mg/kg RS, and combined) compound-treated diabetic groups. The elevated serum blood glucose levels, insulin levels, and dyslipidemia in diabetic rats were significantly improved by QE, RS, and combined treatments. Oxidative stress and tissue injury biomarkers were dramatically inhibited by these compounds. They also shown to improve the hematological parameters which were shown to the hyperlactatemia and ketoacidosis as main causes of diabetic complications. The compounds treatment maintained the activities of hepatic glucose metabolic enzymes and structure of pancreatic ${\beta}-cells$ from the diabetes, and it is noteworthy that cotreatment with QE and RS showed the most preventive effect on the diabetic rats. Therefore, our study suggests that cotreatment with QE and RS has beneficial effects against diabetes. We further suggest that cotreatment with QE and RS has the potential for use as an alternative therapeutic strategy for diabetes.
#Diabetes #Quercetin #Resveratrol #Streptozotocin #Glucose

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참고문헌 (41)

참고문헌 신청
American Diabetes Association / 2010 / Diagnosis and classification of diabetes mellitus / Diabetes Care 33:S62~S69 Crossref Arias, N. / 2016 / The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue / Eur. J. Nutr. 55:341~348 google schola Baquer, N. Z. / 1976 / Effects of thyroid hormone deficiency on the distribution of hepatic metabolites and control of pathways of carbohydrate metabolism in liver and adipose tissue of the rat / Eur. J. Biochem. 68:403~413 Crossref Ceriello, A. / 2005 / Postprandial hyperglycemia and diabetes complications: is it time to treat? / Diabetes 54:1~7 Crossref Cersosimo, E. / 2014 / Assessment of pancreatic beta-cell function: review of methods and clinical applications / Curr. Diabetes Rev. 10:2~42 Crossref

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