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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한지역사회영양학회 대한지역사회영양학회지 대한지역사회영양학회지 제10권 제6호
발행연도
2005.12
수록면
963 - 970 (8page)

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연구주제
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Recently elevated plasma homocysteine concentration is considered an independent risk factor for atherosclerosis and thrombosis with coronary artery disease. Folate vitamin B₁₂ are cofactors and closely related with metabolism of homocysteine. The purpose of this study is to evaluate the correlation between homocysteine and folate and vitamin B₁₂ in patients with ischemic heart disease. Twenty-six patients, in whom coronary angiographic finding revealed more than 50% of stenosis at least in one coronary vessel were enrolled as the patient group, and thirty subjects, in whom angiographic finding revealed in not significant stenosis, but complained of chest pain, were selected as the control group. Fasting venous blood was obtained and measured the concentration of plasma total homocysteine, folate and vitamin B₁₂ by high performance liquid chromatography and fluorescence detection method. We examined the correlation between homocysteine and folate and/or vitamin B₁₂ in the control group and the patient group, respectively. Compared with the control group, the patient group had relatively higher plasma total homocysteine concentration (10.7 ± 4.2 vs 9.6 ± 3.5 umol/L), but showed non significant difference. Folate and vitamin B₁₂ concentration are low in the patient group, but showed no significant difference between patient and control group. Plasma total homocysteine concentration showed negative correlation with folate and vitamin B₁₂ in both the control group and the patient group, and showed significantly negative correlation in patient group {r = -0.550 (p < 0.01) vs r = -0.609 (p < 0.01)}. We knew that the plasma total homocysteine concentration were relatively elevated n patient group compared with the control group. Because plasma total homocysteine concentrations are closely negative correlated with folate and vitamin B₁₂ in the patient group, folate and vitamin B₁₂ supplement can lower the mortality and morbidity of ischemic heart disease.

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