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논문 기본 정보

자료유형
학술저널
저자정보
Ki-Woong Kim (KOSHA) Yong Lim Won (KOSHA) Dong Jin Park (KOSHA) Doh-Hee Kim (Seoul Medical Center) Kwan Young Song (Seoul Medical Center)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.30 No.3
발행연도
2014.9
수록면
199 - 204 (6page)

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초록· 키워드

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The aim of this research was to improve our understanding of human toxicity due to exposure to DMF, MEK, or TOL individually as compared to exposure to DMF-MEK or DMF-TOL mixtures, by comparing EC<SUB>50</SUB> values as well as the morphological changes in HepG2 cells treated with these substances. We found that there was marked cell necrosis in the groups treated with mixtures than in those treated with the compounds alone, and that the amount of cell death and the EC<SUB>50</SUB> value were more dependent on MEK and TOL than on DMF. Moreover, analysis of the changes in effective concentration curves revealed that MEK had an antagonistic effect on the human toxicity of DMF, whereas TOL had a synergistic effect. Accordingly, these results suggest that in workplaces involved in the manufacture of synthetic leather, mixtures of DMF and TOL should be avoided as much as possible in order to minimize environmental toxicity and protect the health of the workers.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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