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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 141 - 148 (8page)
이용수
초록· 키워드
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Endothelium-derived relaxing factors (EDRFs), including nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF), play pivotal roles in regulating vascular tone. Reduced EDRFs cause impaired endothelium-dependent vasorelaxation, or endothelial dysfunction. Impaired endothelium-dependent vasorelaxation in response to acetylcholine (ACh) is consistently observed in conduit vessels in human patients and experimental animal models of hypertension. Because small resistance arteries are known to produce more than one type of EDRF, the mechanism(s) mediating endothelium-dependent vasorelaxation in small resistance arteries may be different from that observed in conduit vessels under hypertensive conditions, where vasorelaxation is mainly dependent on NO. EDHF has been described as one of the principal mediators of endothelium-dependent vasorelaxation in small resistance arteries in normotensive animals. Furthermore, EDHF appears to become the predominant endothelium-dependent vasorelaxation pathway when the endothelial NO synthase (NOS3)/NO pathway is absent, as in NOS3-knockout mice, whereas some studies have shown that the EDHF pathway is dysfunctional in experimental models of hypertension. This article reviews our current knowledge regarding EDRFs in small arteries under normotensive and hypertensive conditions.
목차
ENDOTHELIUM-DERIVED RELAXING FACTORS (EDRFS)
ENDOTHELIAL DYSFUNCTION IN HYPERTENSION
PERSPECTIVES
REFERENCES
참고문헌 (77)
참고문헌 신청
Furchgott, R.F. / 1980 / The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine / Nature 288:373~376
Vanhoutte, P. M. / 1989 / Endothelium and control of vascular function. State of the Art lecture / Hypertension 13:658~667
Luscher, T.F. / 1997 / Biology of the endothelium / Clin. Cardiol 20
Palmer, R. M. / 1987 / Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor / Nature 327:524~526
Dudzinski, D. M. / 2006 / The regulation and pharmacology of endothelial nitric oxide synthase / Annu. Rev. Pharmacol. Toxicol 46:235~276
Vanhoutte, P. M. / 1989 / Endothelium and control of vascular function. State of the Art lecture / Hypertension 13:658~667
Luscher, T.F. / 1997 / Biology of the endothelium / Clin. Cardiol 20
Palmer, R. M. / 1987 / Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor / Nature 327:524~526
Dudzinski, D. M. / 2006 / The regulation and pharmacology of endothelial nitric oxide synthase / Annu. Rev. Pharmacol. Toxicol 46:235~276
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UCI(KEPA) : I410-ECN-0101-2015-510-002798730