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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.18 No.3
- 발행연도
- 2013.9
- 수록면
- 169 - 174 (6page)
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The acute and subacute hypoglycemic and antihyperglycemic effects of drinkable ripe onion juice (Commercial product name is “Black Onion Extract”) were investigated in normal and streptozotocin-induced diabetic rats. For tests of acute and subacute hypoglycemic effects, ripe onion juice (5 and 15 mL/kg b.w.) was administered by oral gavage to normal Sprague Dawley rats and measurements of fasting glucose levels and oral glucose tolerance tests were performed. Tolbutamide was used as a reference drug at a single oral dose of 250 mg/kg b.w. To test anti-hyperglycemic activity, the ripe onion juice was administered to streptozotocin-induced diabetic rats by oral gavage at single dose of 15 mL/kg b.w. per day for 7 consecutive days. Oral administration of the ripe onion juice at either dosed level of 5 or 15 mL/kg b.w. showed no remarkable acute hypoglycemic effect in normal rats. The two dosed levels caused a relatively small reduction, only 18% and 12% (5 and 15 mL/kg b.w., respectively) decrease in glucose levels at 2 h after glucose loading in normal rats. However, at 3 h after glucose loading, blood glucose levels in the ripe onion juice-dosed rats were decreased to the corresponding blood glucose level in tolbutamide-dosed rats. Although showing weak hypoglycemic potential compared to that of tolbutamide, oral administration of ripe onion juice (15 mL/kg b.w.) for a short period (8 days) resulted in a slight reduction in the blood glucose levels that had elevated in Streptozotocin-induced diabetic rats. In conclusion, these results suggest that the commercial product “Black Onion Extract” may possess antihyperglycemic potential in diabetes.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus / 1997 / Report of the expert committee on the diagnosis and classification of diabetes mellitus / Diabetes Care 20 : 1183 ~ 1197
2. [학술지(정기간행물)] - DeFronzo RA / 1997 / Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes / Diabetes Rev 5 : 177 ~ 269
3. [학술지(정기간행물)] - Srinivasan K. / 2005 / Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts / Int J Food Sci Nutr 56 : 399 ~ 414
4. [학술지(정기간행물)] - Virtanen AL / 1976 / The isolation of S-methyl- L-cysteine sulphoxide and S-n-propyl-L-cysteine sulphoxide from onion (Allium cepa) and the antibiotic activity of crushed onion / Acta Chem Scand 13 : 1898 ~ 1900
5. [학술지(정기간행물)] - Block E / 1985 / The chemistry of garlic and onions / Sci Am 252 : 94 ~ 99
2. [학술지(정기간행물)] - DeFronzo RA / 1997 / Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes / Diabetes Rev 5 : 177 ~ 269
3. [학술지(정기간행물)] - Srinivasan K. / 2005 / Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts / Int J Food Sci Nutr 56 : 399 ~ 414
4. [학술지(정기간행물)] - Virtanen AL / 1976 / The isolation of S-methyl- L-cysteine sulphoxide and S-n-propyl-L-cysteine sulphoxide from onion (Allium cepa) and the antibiotic activity of crushed onion / Acta Chem Scand 13 : 1898 ~ 1900
5. [학술지(정기간행물)] - Block E / 1985 / The chemistry of garlic and onions / Sci Am 252 : 94 ~ 99
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UCI(KEPA) : I410-ECN-0101-2014-510-002839625