Drug Resistance and in Vitro Susceptibility of Plasmodium falciparum in Thailand during 1988-2003

Nantana Suwandittakul; Wanna Chaijaroenkul; Pongchai Harnyuttanakorn; Mathirut Mungthin; Kesara Na Bangchang

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자료유형: 학술저널

저자정보: Nantana Suwandittakul (Thammasat University) Wanna Chaijaroenkul (Thammasat University) Pongchai Harnyuttanakorn (Chulalongkorn University) Mathirut Mungthin (Phramongkutklao College of Medicine) Kesara Na Bangchang (Thammasat University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.47 No.2

발행연도: 2009.6

수록면: 139 - 144 (6page)

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The aim of the present study was to investigate antimalarial drug pressure resulting from the clinical use of different antimalarials in Thailand. The phenotypic diversity of the susceptibility profiles of antimalarials, i.e., chloroquine (CQ), quinine (QN), mefloquine (MQ), and artesunate (ARS) in Plasmodium falciparum isolates collected during the period from 1988 to 2003 were studied. P. falciparum isolates from infected patients were collected from the Thai-Cambodian border area at different time periods (1988-1989, 1991-1992, and 2003), during which 3 different patterns of drug use had been implemented: MQ + sulphadoxine (S) + pyrimethamine (P), MQ alone and MQ + ARS, respectively. The in vitro drug susceptibilities were investigated using a method based on the incorporation of [3H] hypoxanthine. A total of 50 isolates were tested for susceptibilities to CQ, QN, MQ, and ARS. Of these isolates, 19, 16, and 15 were adapted during the periods 1988-1989, 1991-1993, and 2003, respectively. P. falciparum isolates collected during the 3 periods were resistant to CQ. Sensitivities to MQ declined from 1988 to 2003. In contrast, the parasite was sensitive to QN, and similar sensitivity profile patterns were observed during the 3 time periods. There was a significantly positive but weak correlation between the IC50 values of CQ and QN, as well as between the IC50 values of QN and MQ. Drug pressure has impact on sensitivity of P. falciparum to MQ. A combination therapy of MQ and ARS is being applied to reduce the parasite resistance, and also increasing the efficacy of the drug.

#Plasmodium falciparum #in vitro testing #Thailand #drug pressure

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