지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.18 No.1
- 발행연도
- 2013.3
- 수록면
- 11 - 17 (7page)
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초록· 키워드
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Dysfunction of endothelial cells is considered a major cause of vascular complications in diabetes. In the present study, we investigated the protective effect of Padina arborescens extract against high glucose-induced oxidative damage in human umbilical vein endothelial cells (HUVECs). High-concentration of glucose (30 mM) treatment induced cytotoxicity whereas Padina arborescens extract protected the cells from high glucose-induced damage and significantly restored cell viability. In addition, lipid peroxidation, intracellular reactive oxygen species (ROS), and nitric oxide (NO) levels induced by high glucose treatment were effectively inhibited by treatment of Padina arborescens extract in a dose-dependent manner. High glucose treatment also induced the overexpressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and NF-κB proteins in HUVECs, but Padina arborescens extract treatment reduced the overexpressions of these proteins. These findings indicate the potential benefits of Padina arborescens extract as a valuable source in reducing the oxidative damage induced by high glucose.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Ames B / 1998 / Micronutrients prevent cancer and delay aging / Toxicol Lett 102 : 5 ~ 18
2. [학술지(정기간행물)] - Baynes JW / 1999 / Role of oxidative stress in diabetic complications : a new perspective on an old paradigm / Diabetes 48 : 1 ~ 9
3. [학술지(정기간행물)] - Kukidume D / 2006 / Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells / Diabetes 55 : 120 ~ 127
4. [학술지(정기간행물)] - Susztak K / 2006 / Glucoseinduced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy / Diabetes 55 : 225 ~ 233
5. [학술지(정기간행물)] - Osakabe N / 2004 / Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats / Exp Biol Med 229 : 33 ~ 39
2. [학술지(정기간행물)] - Baynes JW / 1999 / Role of oxidative stress in diabetic complications : a new perspective on an old paradigm / Diabetes 48 : 1 ~ 9
3. [학술지(정기간행물)] - Kukidume D / 2006 / Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells / Diabetes 55 : 120 ~ 127
4. [학술지(정기간행물)] - Susztak K / 2006 / Glucoseinduced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy / Diabetes 55 : 225 ~ 233
5. [학술지(정기간행물)] - Osakabe N / 2004 / Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats / Exp Biol Med 229 : 33 ~ 39
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UCI(KEPA) : I410-ECN-0101-2014-500-003115824