지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : To examine the in vitro antioxidant and hepatoprotective properties of Amomum xanthoides extract and its fractions.
Methods : Methanol extract of Amomum xanthoides was fractionated into three fractions; petroleum ether fraction (PFAX), water fraction (WFAX) and ethyl acetate fraction (AFAX). The antioxidant and hepatoprotective effects of these fractions were compared by in vitro experiments.
Results : The total phenols content and DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity was found significant in AFAX when compared with other fractions (PFAX, WFAX). AFAX significantly inhibited NO production by RAW 264.7 cells in LPS-activated condition. In Hep G2 cells, AFAX markedly prevented the leakage of LDH and release of AST against CCl4 challenge.
Conclusion : Amomum xanthoides and especially ethyl acetate fraction have potent antioxidative and hepatoprotective properties.
Methods : Methanol extract of Amomum xanthoides was fractionated into three fractions; petroleum ether fraction (PFAX), water fraction (WFAX) and ethyl acetate fraction (AFAX). The antioxidant and hepatoprotective effects of these fractions were compared by in vitro experiments.
Results : The total phenols content and DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity was found significant in AFAX when compared with other fractions (PFAX, WFAX). AFAX significantly inhibited NO production by RAW 264.7 cells in LPS-activated condition. In Hep G2 cells, AFAX markedly prevented the leakage of LDH and release of AST against CCl4 challenge.
Conclusion : Amomum xanthoides and especially ethyl acetate fraction have potent antioxidative and hepatoprotective properties.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Park BH / 2001 / The protective effect of Amomum xanthoides extract alloxan-induced diabetes through the suppression of NF- κB activation / Exp Mol Med. 33 : 64 ~ 68
2. [학술지(정기간행물)] - Kwon KB / 2003 / Amomum xanthoides extract prevents cytokine-induced cell death of RINm5F cells through the inhibition of nitric oxide formation / Life Sci. 73 : 181 ~ 191
3. [학술지(정기간행물)] - Kim SH / 2005 / Amomum xanthoides inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production / Exp Biol Med. 230 : 681 ~ 687
4. [학술지(정기간행물)] - Zhu JZ / 2001 / Effects of Amomum villosum on gastrointestinal motility and neurotransmitters in rats / Chinese Journal of Integrated Traditional and Western Medicine on Digestion 9 (4) : 205 ~ 207
5. [학술지(정기간행물)] - Feng GW / 2006 / Effect of Amomum villosum extraction on the contraction of rabbit thoracic aorta in vitro / Lishizhen Medicine and Materia Medica Research 17 (11) : 2223 ~ 2225
2. [학술지(정기간행물)] - Kwon KB / 2003 / Amomum xanthoides extract prevents cytokine-induced cell death of RINm5F cells through the inhibition of nitric oxide formation / Life Sci. 73 : 181 ~ 191
3. [학술지(정기간행물)] - Kim SH / 2005 / Amomum xanthoides inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production / Exp Biol Med. 230 : 681 ~ 687
4. [학술지(정기간행물)] - Zhu JZ / 2001 / Effects of Amomum villosum on gastrointestinal motility and neurotransmitters in rats / Chinese Journal of Integrated Traditional and Western Medicine on Digestion 9 (4) : 205 ~ 207
5. [학술지(정기간행물)] - Feng GW / 2006 / Effect of Amomum villosum extraction on the contraction of rabbit thoracic aorta in vitro / Lishizhen Medicine and Materia Medica Research 17 (11) : 2223 ~ 2225
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UCI(KEPA) : I410-ECN-0101-2014-519-000262483