지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background and Objectives: The skin barrier protects skin against a harmful environment. Its function includes an antimicrobial barrier as well as a physical barrier. Stress is harmful to the skin barrier and there are many studies on this, but there are few about the effect of stress during pregnancy on the skin barrier of offspring. The aim of this study was to investigate the effect of stress during pregnancy on the skin barrier of offspring by examination with the naked eye, cortisol, weight, TEWL and histologic tests.
Materials and Methods: Male hairless mice ten weeks old were coupled with females for three days. After twelve days the females were divided into two groups. We stressed one group and not the other group. The offspring from the non-stressed (N group) and stressed (S group) grew up until four weeks. The S group was exposed to chronic mild stress using the chronic stress model protocol modified method of Wilner and Towell for a week. We made examinations with the naked eye, assessment of cortisol, weight, TEWL, and histologic test to contrast the S group with the N group. Statistical analysis was performed by using Mann-Whitney and Friedman test. Statistical significance was achieved if the probability was less than 5% (p<0.05)
Results:
1. By making an examination with the naked eye, S group showed papules, creases and dryness on their skin, but N showed no change compared with normal skin.
2. There was no statistically significant difference between S group and N group in cortisol (p>0.05).
3. There was no statistically significant difference between S group and N group in weight. N group had less weight than S group (p<0.05).
4. There was no statistically significant difference between S group and N group in TEWL (p>0.05).
5. There was no statistically significant difference between S group and N group in TEWL recovery (p>0.05).
6. In TEWL and TEWL recovery, there was statistically significant difference by time between S group and N group (p<0.005).
7. Histologically, S group showed a thicker epidermis and epidermal crest than N group.
Conclusions: We found that stress during pregnancy has negative effects on the skin barrier of offspring. Though there were no statistically significant differences between S group and N group in TEWL recovery, we found evidence that the recovery of skin barrier function is interrupted by stress during pregnancy by examination with both the naked eye and histology.
Materials and Methods: Male hairless mice ten weeks old were coupled with females for three days. After twelve days the females were divided into two groups. We stressed one group and not the other group. The offspring from the non-stressed (N group) and stressed (S group) grew up until four weeks. The S group was exposed to chronic mild stress using the chronic stress model protocol modified method of Wilner and Towell for a week. We made examinations with the naked eye, assessment of cortisol, weight, TEWL, and histologic test to contrast the S group with the N group. Statistical analysis was performed by using Mann-Whitney and Friedman test. Statistical significance was achieved if the probability was less than 5% (p<0.05)
Results:
1. By making an examination with the naked eye, S group showed papules, creases and dryness on their skin, but N showed no change compared with normal skin.
2. There was no statistically significant difference between S group and N group in cortisol (p>0.05).
3. There was no statistically significant difference between S group and N group in weight. N group had less weight than S group (p<0.05).
4. There was no statistically significant difference between S group and N group in TEWL (p>0.05).
5. There was no statistically significant difference between S group and N group in TEWL recovery (p>0.05).
6. In TEWL and TEWL recovery, there was statistically significant difference by time between S group and N group (p<0.005).
7. Histologically, S group showed a thicker epidermis and epidermal crest than N group.
Conclusions: We found that stress during pregnancy has negative effects on the skin barrier of offspring. Though there were no statistically significant differences between S group and N group in TEWL recovery, we found evidence that the recovery of skin barrier function is interrupted by stress during pregnancy by examination with both the naked eye and histology.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (9)
참고문헌 신청
1. [학술지(정기간행물)] - Dhabhar FS / 1994 / Diurnal and acute stress-induced changes in distribution of peripheral blood leukocyte subpopulations / Brain Behav Immunol 8 (1) : 66 ~ 79
2. [학술지(정기간행물)] - Zouboulis CC / 2002 / Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes / Proc Natl Acad Sci 99 (10) : 7148 ~ 7153
3. [학술지(정기간행물)] - Mulder MM / 2001 / Psychosocial impact of acne vulgaris. evaluation of the relation between a change in clinical acne severity and psychosocial state / Dermatology 203 (2) : 124 ~ 130
4. [학술지(정기간행물)] - Chiu A / 2003 / response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress / Arch Dermatol 139 (7) : 897 ~ 900
5. [단행본] - Lee SH / 2004 / Skin barrier / Ryumunkak : 14 ~
2. [학술지(정기간행물)] - Zouboulis CC / 2002 / Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes / Proc Natl Acad Sci 99 (10) : 7148 ~ 7153
3. [학술지(정기간행물)] - Mulder MM / 2001 / Psychosocial impact of acne vulgaris. evaluation of the relation between a change in clinical acne severity and psychosocial state / Dermatology 203 (2) : 124 ~ 130
4. [학술지(정기간행물)] - Chiu A / 2003 / response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress / Arch Dermatol 139 (7) : 897 ~ 900
5. [단행본] - Lee SH / 2004 / Skin barrier / Ryumunkak : 14 ~
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UCI(KEPA) : I410-ECN-0101-2014-519-000284312