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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제1권 제1호
- 발행연도
- 2013.1
- 수록면
- 20 - 28 (9page)
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Atopic dermatitis is a chronic relapsing eczematous dermatosis, which usually starts in childhood, and various causes are intricately associated with the development of the disease. Recently, various abnormalities in barrier function have been identified as the cause of atopic dermatitis. Loss-of-function mutation of filaggrin, a significant constituent of skin barrier, has been revealed as a cause for atopic dermatitis, and factors like enhanced protease activity, and decreased synthesis of the lipid lamellae especially ceramides also plays an important role in barrier dysfunction. Not only these genetic causes but also environmental factors are associated in barrier dysfunction, such as soap or detergents which increases skin pH, or proteases of dust mites or cockroaches which enhances epidermal barrier breakdown. Lately, skin barrier dysfunction is also thought to play an important role in the early stage of other allergic diseases such as asthma. Therefore, comprehension of the function of skin barrier can provide help in understanding various allergic diseases.
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참고문헌 (25)
참고문헌 신청
Bieber T / 2008 / Atopic dermatitis / N Engl J Med 358 : 1483 ~ 1494
Candi E / 2005 / The cornified envelope: a model of cell death in the skin / Nat Rev Mol Cell Biol 6 : 328 ~ 340
De Benedetto A / 2011 / Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis / J Allergy Clin Immunol 128 : 242 ~ 246
De Benedetto A / 2011 / Tight junction defects in patients with atopic dermatitis / Allergy Clin Immunol 127 : 773 ~ 786
De Benedetto A / 2012 / Skin barrier disruption: a requirement for allergen sensitization? / J Invest Dermatol 132 (3 Pt 2) : 949 ~ 963
Candi E / 2005 / The cornified envelope: a model of cell death in the skin / Nat Rev Mol Cell Biol 6 : 328 ~ 340
De Benedetto A / 2011 / Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis / J Allergy Clin Immunol 128 : 242 ~ 246
De Benedetto A / 2011 / Tight junction defects in patients with atopic dermatitis / Allergy Clin Immunol 127 : 773 ~ 786
De Benedetto A / 2012 / Skin barrier disruption: a requirement for allergen sensitization? / J Invest Dermatol 132 (3 Pt 2) : 949 ~ 963
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