결장직장암에서 혈소판 증가증의 임상적 의의

신현욱; 홍성우; 장여구; 한구용; 백인욱; 이혁상

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자료유형: 학술저널

저자정보: 신현욱 (인제대학교) 홍성우 (인제대학교) 장여구 (인제대학교) 한구용 (인제대학교) 백인욱 (인제대학교) 이혁상 (인제대학교)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.73 No.1

발행연도: 2007.7

수록면: 31 - 35 (5page)

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Purpose: Thrombocytosis is commonly associated with various tumors, including stomach, ovarian, lung, liver and pancreas cancers. Some clinical reports have shown thrombocytosis to be associated with the disease stage and prognosis. This study investigated the prevalence of the thromobocytosis in patients with colorectal cancer, and its association with the prognosis.
Methods: Two hundreds ninety-six patients with colorectal cancer who had been surgically treated at our hospital between 1997 and 2004 were enrolled in this study. The incidence, relationship with other clinicopathological factors, and the prognostic value of thrombocytosis were evaluated retrospectively.
Results: Thirty-seven of the 290 (12.8%) patients had thrombocytosis. The incidence of thrombocytosis was examined with regard to gender (P=0.018), tumor location (P=0.021), and T stage of tumor (P＜0.000). Univariate analysis demonstrated thromobocytosis, T stage, N stage, M stage, venous invasion, lymphatic invasion, and elevated carcinoembryogenic antigen (≥5 ng/ml) to be associated with both the disease-free survival (DFS) and overall survival (OS). Multivariate analysis revealed thrombocytosis to be significantly associated with the disease-free survival (P=0.026).
Conclusion: Preoperative thrombocytosis appears to be an independent prognostic indicator of the DFS in patients with colorectal cancer.

#Colorectal cancer #Thrombocytosis #Prognosis #결장직장암 #혈소판 증가증 #예후

참고문헌 (25)

참고문헌 신청

1. [학술지(정기간행물)] - Riess L. / 1872 / Zur pathologischen anatomie des blutes / Arch Anat Physiol Wissensch Med 39 : 234 ~ 249

2. [단행본] - Arnold SM / 2005 / Paraneoplastic syndrome, In Cancer: Principles and Practice of Oncology. 7th ed / Lippincott Williams and Wilkins : 2193 ~ 2196

3. [학술지(정기간행물)] - Costantini V / 1990 / The platelet count in carcinoma of the lung and colon / Thromb Haemost 64 : 501 ~ 505

4. [학술지(정기간행물)] - Symbas NP / 2000 / Poor prognosis associated with thrombocytosis in patients with renal cell carcinoma / BJU Int 86 : 203 ~ 207

5. [학술지(정기간행물)] - Rodriguez GC / 1994 / The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer / Obstet Gynecol 83 : 445 ~ 448

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